Synthesis, Characterization, Hydrolytic Stability, Nickel(II) Chloride Complex and Anti-Parasitic Activity of Pyrene-Tethered Silatranes

Heterocycle-derived organosilatranes as naked eye sensors for Sn2+ ions and their potential inhibiting activity against HIV-1 protease via a computational approach

“…, trialkoxysilanes, therefore reducing the sensitivity to hydrolysis. 28,29 The area of silatranes is fast progressing, being employed as materials research objects and powerful biological active agents in biology and medicine for anti-bacterial, anti-inflammatory and anti-cancer activities. 30,31 In the present work, we emphasize the development of a naked eye probe for the detection of Sn 2+ ions by using a simple synthetic procedure.…”

“…27 Silatranes are cyclic ethers of trialkanolamines with the general formula XSi (OCR 2 CR 2 ) 3 N, a kind of tricyclic cage having a transannular dative bond between the silicon and nitrogen atom, which provides stability compared to their open-chain counterparts i.e., trialkoxysilanes, therefore reducing the sensitivity to hydrolysis. 28,29 The area of silatranes is fast progressing, being employed as materials research objects and powerful biological active agents in biology and medicine for anti-bacterial, antiinflammatory and anti-cancer activities. 30,31 In the present work, we emphasize the development of a naked eye probe for the detection of Sn 2+ ions by using a simple synthetic procedure.…”