YouTube is one of the most known and used social networks among students in the world, and undergraduate chemistry students are no exception. Undeniably, YouTube can offer several advantages for complementing university lessons in an asynchronous manner. There are many chemistry channels available on the internet; however, they are mainly too general or run by nonprofessionals, resulting in misconceptions or inaccuracies that lead to student confusion. In this contribution, we present CADMIO, a peer-to-peer reviewed YouTube channel with more than 60 videos in Spanish language, 2,550 subscribers, and 6,000 hours of accumulated views over the first year. These videos focus on introductory and advanced topics in inorganic chemistry. CADMIO is a powerful, versatile, and useful didactic tool, in which each video lesson presents basic concepts in a clear and concise way, thorough methodologies to enhance problem-solving skills, and an important variety of exercises to help students learning. The wonderful and outstanding response of CADMIO on the web and in the Faculty of Chemistry encourages us to improve the channel, and recently, it has even become a Social Service program in Mexico. Our unique concept for revised video content, secured by an editorial board consisting of professors at the Facultad de Quı́mica, UNAM, make CADMIO a truthful tool for teaching and learning chemistry.

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A systematic, rational search for chalcone derivatives with multifunctional behavior has been carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 derivatives were constructed by incorporating functional groups into the chalcone structure. Selection scores were calculated from ADME properties, toxicity, and manufacturability descriptors. They were used to select a subset of molecules (23) with the best drug-like behavior. Reactivity indices were calculated for this subset. They were chosen to account for electron and hydrogen atom donating capabilities, which are key processes for antioxidant activity. The indexes showed that four chalcone derivatives (dCHA-279, dCHA-568, dCHA-553, and dCHA-283) are better electron and H donors than the parent molecule and some reference antioxidants (Trolox, ascorbic acid, and α-tocopherol). In addition, based on molecular docking, they are predicted to act as catechol-O-methyltransferase (COMT), acetylcholinesterase (AChE), and monoamine oxidase B (MAO-B) inhibitors. Therefore, these four molecules are proposed as promising candidates to act as multifunctional antioxidants with neuroprotective effects.