Synthesis, characterization, drug-loading capacity and safety of novel octyl modified serum albumin micelles

Gong, Jian Ping; Huo, Meirong; Zhou, Jianping; Zhang, Yong; Peng, Xiaoling; Yu, Di; Zhang, Hui; Li, Jing

doi:10.1016/j.ijpharm.2009.04.033

Cited by 109 publications

(64 citation statements)

References 30 publications

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“…27 The mobile phase was The chromatographic conditions employed were as follows: Lichrospher C18 column 5 mm, 150 mm Â 4.6 mm i.d. ; flow rate was 1.0 mL/min; detection at 227 nm and sample injected volume of 20 mL.…”

Section: In Vitro Characterization Of Ptx-loaded Dhc Micellesmentioning

confidence: 99%

Enhanced Oral Absorption of Paclitaxel in N-Deoxycholic Acid-N, O-Hydroxyethyl Chitosan Micellar System

Huo

Zhou

et al. 2010

Journal of Pharmaceutical Sciences

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Section: In Vitro Characterization Of Ptx-loaded Dhc Micellesmentioning

confidence: 99%

Enhanced Oral Absorption of Paclitaxel in N-Deoxycholic Acid-N, O-Hydroxyethyl Chitosan Micellar System

Huo

Zhou

et al. 2010

Journal of Pharmaceutical Sciences

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“…[9] Lower CMC conferred by two different strategies: (1) Increasing the chain length of the core-forming polymer. [10] (2) Decreasing the chain length of hydrophilic shell-forming polymer. [11] STRUCTURE AND COMPOSITION Polymeric micelles are formed by self-assembly of amphiphilic polymers in an aqueous environment.…”

Section: Micelle Formation Mechanismmentioning

confidence: 99%

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Esfahani¹

2017

AJP

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Almost half of the orally administered drugs are poorly soluble in water; therefore they have low absorption in the gastrointestinal (GI) tract. In addition, drugs which are administered orally must remain stable during passing the GI tract, despite different physiologic challenges such as pH changes, and dilution effect. Hence, new methods are needed to increase the solubility of these drugs while making them more stable in the physiologic environment. Polymeric micelles are one of the new nanocarriers which are able to increase the solubility of these drugs while protecting them from pH changes, dilution effect, and biological barriers such as filtration in the spleen or scavenging by the phagocytic system. This article provides some important and basic information including polymeric micelles characteristics, structure, and preparation.

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“…Selfassemblies prepared from amphiphilic block copolymers show the CMCs in the 10 -6 -10 -9 molar range, which is low enough to keep the integrity of the self-assemblies in the body and thus providing suitable drug delivery platforms [5]. Block copolymers with a charged segment, on the other hand, require oppositely charged counterparts, which include ions, metal chelates, block copolymers, homopolymers and any other charged natural or synthetic molecules [4,6]. The third driving force, chemical conjugation, is a useful method to prepare nanoassemblies that can overcome the thermodynamic limitations at various temperatures, concentrations, pressure and in the complex biological environment.…”

Section: Driving Force and Block Copolymer Nanoassembliesmentioning

confidence: 99%

Block copolymer nanoassemblies

Bae¹

2015

Nanoparticles for Biotherapeutic Delivery (Volume 2)

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His research is focused on elucidating the mechanisms by which bioresponsive block copolymer nanoassemblies carry various molecular payloads in the body for diagnosis, imaging and treatment of human diseases, such as cancer, and thus developing novel nanotechnology-based therapeutic options for personalized therapy in future clinical applications. He has published numerous peer-reviewed papers in scientific journals and served as a conference meeting organizer and a reviewer for domestic and international grant applications as well as scientific papers (one of the Elsevier top reviewers in the subject area of Pharmaceutical Sciences in 2012). He is also an inventor of several issued and provisional patents related to engineering, pharmaceutical and biological applications using polymer nanoassemblies.2

show abstract

Synthesis, characterization, drug-loading capacity and safety of novel octyl modified serum albumin micelles

Cited by 109 publications

References 30 publications

Enhanced Oral Absorption of Paclitaxel in N-Deoxycholic Acid-N, O-Hydroxyethyl Chitosan Micellar System

Enhanced Oral Absorption of Paclitaxel in N-Deoxycholic Acid-N, O-Hydroxyethyl Chitosan Micellar System

Untitled

Block copolymer nanoassemblies

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