Synthesis, characterization, DNA binding and cytotoxicity studies of moxifloxacinato complexes

Singh, Rajinder; Jadeja, Ravirajsinh N.; Thounaojam, Menaka C.; Devkar, Ranjitsinh; Chakraborty, Debkumar

doi:10.1007/s11243-012-9620-5

Cited by 15 publications

(9 citation statements)

References 29 publications

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“…Hence, this method provides an indirect evidence for the intercalative binding mode. [48] In the present study, a quenching in the fluorescence emission intensity of EB bound to DNA was observed with the addition of metal complex solution, indicating that the EB molecules are displaced by the added complexes from the DNA binding sites. The fluorescence spectra of EB bound to DNA quenched by the ternary metal complexes are shown in figure 3.…”

Section: Competitive Dna Binding Studiessupporting

confidence: 54%

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Saritha

Reddy

Sireesha

2021

Vietnam Journal of Chemistry

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The synthesis, characterization of mixed ligand chelates of Ni(II), [NiAL] involving Pyridoxalthiosemicarbazone (A) and dipeptides (L) viz., glycyl‐glycine (gly‐gly), glycyl‐L‐leucine (gly‐leu), glycyl‐L‐tyrosine (gly‐tyr) and glycyl‐L‐valine (gly‐val) and their biological activities have been studied. The complexes were characterized based on their elemental analysis, LC‐MS, IR, UV‐Vis spectral studies, magnetic moment, molar conductance and thermal analysis. The mixed ligand complexes were formed with 1:1:1 (Ni:A:L) ratio. The molar conductance data reveal the non‐electrolytic nature of the metal chelates. IR spectra show that the ligands are coordinated to the metal ion in a tridentate manner, involving O,N,S and O,N,N donor sites of ligands, A and L respectively. Based on the analytical data, octahedral geometry has been proposed for the metal complexes. DNA binding properties of the complexes have been investigated by UV‐Vis and fluorescence spectroscopy and also by viscosity measurements. The obtained results indicate that the complexes bind to DNA through intercalation mode, which is further validated by molecular docking studies. The hydrolytic cleavage of the pBR322 DNA from supercoiled to nicked form, by the metal complexes was investigated by gel electrophoresis technique. The metal complexes were also screened for their antioxidant, anti‐inflammatory and antibacterial activities and the findings have been reported.

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Section: Competitive Dna Binding Studiessupporting

confidence: 54%

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Saritha

Reddy

Sireesha

2021

Vietnam Journal of Chemistry

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“…Antibacterial quinolone and fluoro-quinolone species, such as moxifloxacin (MFL) and ciprofloxacin (CPF), have been extensively used together with diimine ligands for synthesis of ternary copper compounds (vide infra), but other examples of copper(II)–quinolones complexes have been reported where the quinolone acted as a bidentate ligand coordinating the metal through ketone and carboxylate oxygens. In a series of five neutral metal complexes [Fe(MFL) 3 ], [V(O)(MFL) 2 ], [Cu(MFL) 2 (H 2 O) 2 ], [Ni(MFL) 2 (H 2 O) 2 ], and [Mn(MFL) 2 ], the copper derivative showed the strongest DNA binding via intercalation and the highest in vitro antiproliferative activity against A549 cancer cells (IC 50 5.4 μg/mL) . Square-pyramidal, ternary Cu(II) complexes 31a – f were prepared with CPF and bidentate N,S-donor ligands ( L 31a – f ; Figure ) .…”

Section: Copper Complexes As Anticancer Agentsmentioning

confidence: 99%

Advances in Copper Complexes as Anticancer Agents

et al. 2013

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Copper is a transition metal that can exist in oxidized (Cu(II)) and reduced (Cu(I)) states. This allows it to participate in redox and catalytic chemistry, making it a suitable cofactor for a diverse range of enzymes and molecules. Copper complexes have been investigated for their therapeutic or diagnostic potential showing effectiveness in cancer treatment due to their cytotoxic action on tumour cells. In this review, the most remarkable achievements in the design and development of copper(I, II) complexes as antitumor agents are discussed. Special emphasis has been focused on the identification of structure-activity relationships for the different classes of complexes. Up to now, despite the enormous efforts in synthesizing different classes of copper complexes, very few data concerning the molecular basis of the mechanisms underlying their antitumor activity are available. The current overview, collecting the most significant strategies adopted in the last four years to design promising anticancer copper(I,II) compounds, aims to provide a useful reference for researchers working in this field

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“…Moxifloxacin complexes with different metal ions (Cu(II), Mn(II), Ni(II), Fe(III), and VO(II)) were further evaluated for cytotoxicity against the human lung carcinoma A549 cell line. All complexes resulted in potentiation of the antitumor activity of their parent drug, where Cu(II) adduct 66 yielded the most potent complex with IC 50 = 5.4 g/mL . A study on the basis of moxifloxacin and gatifloxacin as ternary copper complexes with 2,2'‐bipyridyl and 1,10‐phenanthroline 67 was conducted.…”

Section: Fluoroquinolone Metal Ion Complexes With Anticancer Activitymentioning

confidence: 99%

Towards anticancer fluoroquinolones: A review article

Abdel-AAl

Abdel‐Aziz

Shaykoon

et al. 2019

Archiv der Pharmazie

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Different studies about the anticancer potential of several medically used antibacterial fluoroquinolones have been established. Fluoroquinolone derivatives, like some anticancer drugs, such as doxorubicin, can achieve antitumor activity via poisoning of type II human DNA topoisomerases. Interestingly, structural features required for the anticancer activity of quinolones have been determined. Most of the chemical modifications required to convert antibacterially acting fluoroquinolones into their anticancer analogs were at position 7 and the carboxylic group at position 3. This review highlights the antitumor potential of fluoroquinolones in general and summarizes the chemical modifications carried out on fluoroquinolones to become anticancer agents. Moreover, the review gives a quick recap on metal ion chelates with fluoroquinolones and their substantial role in topoisomerase poisoning and antitumor potential improvement. Hence, it should be highly interesting for researchers attempting to design and synthesize novel anticancer fluoroquinolone candidates. K E Y W O R D S anticancer, DNA topoisomerase, metal ion complexes, quinolones Arch Pharm Chem Life Sci. 2019;352:1800376.wileyonlinelibrary.com/journal/ardp

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Synthesis, characterization, DNA binding and cytotoxicity studies of moxifloxacinato complexes

Cited by 15 publications

References 29 publications

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Synthesis, characterization and biological activity of mixed ligand chelates of Ni(II) with pyridoxalthiosemicarbazone and dipeptides

Advances in Copper Complexes as Anticancer Agents

Towards anticancer fluoroquinolones: A review article

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