Synthesis, characterization, DFT and antimicrobial studies of transition metal ion complexes of a new schiff base ligand, 5-methylpyrazole-3yl-N-(2́-hydroxyphenylamine)methyleneimine, (MPzOAP)

Mandal, Susmita; Das, Mousumi; Das, Piu; Samanta, Amalesh; Butcher, Ray J.; Saha, Manan; Alswaidan, Ibrahim A.; Rhyman, Lydia; Ramasami, Ponnadurai; Saha, Nimai Chandra

doi:10.1016/j.molstruc.2018.09.095

Cited by 12 publications

(8 citation statements)

References 73 publications

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“…Furthermore, 92 was 8-fold more effective than amoxicillin against E. aerogenes (MIC of 92 = 35 µg/mL) [193]. The complex 91 was inactive while 93 showed a MIC value of 10 µg/mL against different V. cholerae strains, P. aeruginosa and M. luteus [194]. Lam et al have reported a series of bis-(alkynyl)mercury(II) complexes with oligothiophene and bithiazole linking units (94 and 95, Figure 16) with remarkable antimicrobial activity against MRSA and C. albicans [195].…”

Section: Cadmium and Mercury Complexesmentioning

confidence: 98%

“…In 2017 and 2018, Mandal et al reported the synthesis, characterization and antimicrobial activities of cadmium(II) and mercury(II) complexes of 5-methyl pyrazole-3yl-N-(2 -methylthiophenyl) methyleneimine [193] and pyrazol-3-yl-N-(2-methoxyphenyl) methanimine [194] (90-93, Figure 16) against a panel of pathogens. In comparison to amoxicillin, cadmium(II) and mercury(II) complexes 90 and 92 showed very good antimicrobial activity against P. vulgaris and S. aureus with MICs of 35 and 25 µg/mL and 5 and 2 µg/mL, respectively (MICs of amoxicillin = 129 and 85 µg/mL, respectively).…”

Section: Cadmium and Mercury Complexesmentioning

confidence: 99%

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Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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Section: Cadmium and Mercury Complexesmentioning

confidence: 98%

Section: Cadmium and Mercury Complexesmentioning

confidence: 99%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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“…The azo-dye ligand and its transition metal complexes were assayed for their in vitro antimicrobial activities against four pathogenic microorganisms by disk diffusion method. [31] The microorganisms used were of pathogenic nature and have been indicated to cause many life-threatening diseases in living organisms. [48] They were two Gram-positive bacteria species (B. subtilis and S. aureus) and two Gram-negative bacteria species (E. coli and P. aeruginosa).…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

Metal complexes of tetradentate azo‐dye ligand derived from 4,4′‐oxydianiline: Preparation, structural investigation, biological evaluation and MOE studies

Deghadi

Mahmoud

Mohamed

2020

Applied Organom Chemis

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The Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Cd (II) complexes were prepared by reaction of its metal chlorides with new azo‐dye ligand (H2L). The ligand derived from 4,4′‐oxydianiline and 2‐amino‐4‐chlorophenol was synthesized in a 1:2 molar ratio. The structure of the ligand and its metal complexes was investigated using different tools such as elemental analysis (C, H, N and M), molar conductivity, IR, UV–vis, 1H‐NMR, mass spectrometry and thermogravimetric and differential thermogravimetric studies. The data showed that the ligand acted as a N,N,O,O‐binegative tetradentate ligand. All metal complexes had a octahedral structure as depicted by spectral and elemental analyses. The conductivity data showed the electrolytic nature of the Cr (III) and Fe (III) complexes while the other complexes were nonelectrolytes. Thermal analysis studies showed the decomposition of the complexes in four to five steps with the weight loss of hydrated water in the first decomposition step followed by the coordinated water and ligand molecules. Biological activity was tested for the prepared compounds against four bacterial species (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) and against two fungal species (Aspergillus fumigatus and Candida albicans). Also, all complexes were screened for anticancer activities against a breast cancer (MCF‐7) cell line. The [Co(L)(H2O)2] complex showed the lowest IC50 value. Molecular docking is a key tool in computer drug design. Therefore, investigation of protein receptors and ligand interaction plays a vital role in the design of structurally based drugs. As a result, docking studies were investigated for H2L ligand, [Mn(L)(H2O)2] and [Ni(L)(H2O)2] complexes with 5KBC, 3V7B and 4G9M receptors.

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“…Antioxidant Activity: The antioxidant activity of pyrazoline derivatives, metal complexes and the standard ascorbic acid were evaluated using DPPH (1,1-diphenyl-2-picryl hydrazyl) and hydrogen peroxide scavenging methods 24 . After the successful investigations of DPPH and hydrogen peroxide assay methods, the comparision of the antioxidant activity of the pyrazoline derivative (L3) (IC 50 value is 94 µg/mL) with that of the metal complexes (IC 50 values of Cu(II), Ni(II), Co(II) and Zn(II) complexes are 48, 68, 72 and 60 µg/ mL, respectively).…”

Section: Absorption Spectral Titrationsmentioning

confidence: 99%

Untitled

2020

IJPSR

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Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment and electronic spectral data, square planar geometry has been suggested for metal complexes. The binding behavior of the complexes with calf thymus DNA has been investigated by electronic absorption spectra and cyclic voltammetry techniques. The DNA binding constants reveal that all these complexes interact with DNA through intercalation binding mode. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. The antioxidant activities of the complexes showed higher activities. Fluorescent studies reveal that the absorption band is shifted towards visible region indicates that the pyrazoline derivatives of metal complexes may exhibit different emission with respect to suitable substituent present in the pyrazoline structural core. Naphthyl group is responsible for the green colour emission due to its conjugation and electronic delocalization within the molecule and leads to longer wavelength. INTRODUCTION: Metal-containing compounds/ complexes offer many distinct advantages over traditional organic i.e., carbon-based compounds in the development of new medicinal lead molecules due to their capability to coordinate ligands/organic molecules 1-6 .

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Synthesis, characterization, DFT and antimicrobial studies of transition metal ion complexes of a new schiff base ligand, 5-methylpyrazole-3yl-N-(2́-hydroxyphenylamine)methyleneimine, (MPzOAP)

Cited by 12 publications

References 73 publications

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Metal complexes of tetradentate azo‐dye ligand derived from 4,4′‐oxydianiline: Preparation, structural investigation, biological evaluation and MOE studies

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