Synthesis, characterization, crystal structures, enzyme inhibition, DNA binding, and electrochemical studies of zinc(II) complexes

Abstract

Five zinc(II) complexes, [Zn(L 1 ) 2 ] (1), [Zn(L 1 ) 2 (phen)H 2 O]·H 2 O (2), [Zn(L 1 ) 2 (bipy)] (3), [Zn(L 2 ) 2 ] (4), and [Zn(L 2 ) 2 (phen)] (5) (where L 1 = 4-nitrophenylacetate, L 2 = phenylacetate, phen = 1,10-phenanthroline and bipy = 2,2′-bipyridine), have been synthesized and characterized by elemental analysis, FT-IR, and multinuclear NMR. Complexes 2, 3, and 4 have been confirmed by single-crystal X-ray diffraction. In 2 and 3, zinc is bonded monodentate to two carboxylates exhibiting distorted trigonal bipyramidal and tetrahedral geometries, respectively, whereas in 4, the carboxylates are bridging bidentate in distorted tetrahedral geometry. The complexes have been screened for electroand biological activities, including DNA interaction and enzyme inhibition studies. The effect of concentration of 1-5 on the activity of enzyme, alkaline phosphatase, showed that an increase in concentration of complex decreased the activity of the enzyme. Electrochemical behavior of HL 1 , 2, and 3 was investigated by cyclic voltammetry and it was observed that ligand-centered electroactivity exhibits a proportionate change on complexation. The UV-visible spectroscopic and viscometric data indicate electrostatic and groove binding of the complexes with DNA. The binding constant and Gibb's free energy values indicate the feasibility of the complex-DNA interaction and show potent biological activity of the complexes.

Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

“…Zinc carboxylates [35,36,16], amines [37,38] and zinc complexes with Schiff-base ligands [17,39] with similar stable configuration of bioactive metal (like silver) are produced and studied from different points of view (structural, spectral, antimicrobial, cytotoxic, etc. ).…”

“…Development of new active metal complexes that have antibacterial [10,11] or antimicrobial properties [12][13][14][15], enzyme inhibition activity [16] and interact with biomolecules (proteins, DNA) has been a subject of intensive investigation [17,18].…”

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

“…Organic ligands in these complexes affect and regulate their activity by neutralizing the charge on copper ion and facilitating the transport across the cell membranes. 26,27 Therefore, keeping in view all these facts, as well as in continuation of our previous work, [28][29][30] the present study is designed with aim to synthesize biologically active heteroleptic copper(II) complexes with substituted phenylacetic acids and 1,10-phenanthroline and 2,2'-bipyridine. DNA binding ability of synthesized complexes was evaluated through UV-Visible spectroscopy which exhibited good results and their strong enzyme inhibition capacity revealed their therapeutic applications as well.…”

Synthesis, crystal structure, Hirshfeld surface and void analysis of bis(μ2-4-aminobenzoato-κ2 O:O′)bis[bis(4-aminobenzoato-κ2 O,O′)diaquathulium(III)] dihydrate

“…In particular, the lanthanide contraction along the series is of interest, and in a detailed analysis of this phenomenon using elements from the lanthanide series, p-aminobenzoic acid (HL) was found to be a very useful and biologically important ligand (Smith & Lynch, 2015). The carboxylate group of HL can be coordinated with the metals simultaneously in three different modes, namely chelating, bridging, and chelating-bridging (Ali et al, 2014). In the complexes of HL with alkali metals such as Na + or K + , the ligand is not directly coordinated to the metal ion, but rather it is surrounded by coordinated water molecules (You et al, 2021).…”