Synthesis, characterization, crystal structure, and DNA binding of two copper(II)–hydrazone complexes

Nandy, Madshusudan; Hughes, David L.; Rosair, Georgina M.; Singh, Raj K.; Mitra, Samiran

doi:10.1080/00958972.2014.964697

Cited by 31 publications

(12 citation statements)

References 53 publications

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“…32 The C1-O1 and C8-O4 bond lengths of complex (1.289(3) and 1.283(3) Å, respectively) and C1-N1 and C8-N8 (1.331(3) and 1.314(3) Å, respectively) are similar and are in good agreement with analogous Cu(II) complexes observed in the literature where a hydrazone ligand coordinates to the Cu(II) center in its iminolate form. 2,13,14,25,33 The average of Cu-O bond lengths in the dinuclear complex (1.978 Å) is very similar to the corresponding distances in previously reported mononuclear copper(II) complex (1.978 Å). 22 However, the average of Cu-N bond lengths in the dinuclear complex (1.992 Å) is longer than the corresponding bonds in mononuclear copper(II) complex (1.918 Å).…”

Section: Description Of Crystal Structure Of the Complexsupporting

confidence: 63%

Synthesis and Structural Characterization of a Double Helical Dinuclear Copper(II) Complex With Tetradentate Biacetyl Bis(benzoylhydrazone)

Vafazadeh

Abdollahi²,

Willis³

2017

ACSi

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The reaction of tetradentate hydrazone ligand H 2 babh with Cu(CH 3 COO) 2 in methanol solvent leads to the formation of the mono-nuclear complex [Cu(babh)]. However, on being dissolved in dichloromethane solvent and on addition of ethanol solvent, a dinuclear complex of [Cu 2 (μ 1,3 -babh) 2 (C 2 H 5 OH) 2 ] is obtained. The X-ray crystallography indicates that the dinuclear helical complex formation is caused due to the unsymmetrical twisting of the H 2 babh ligand. One oxygen and two nitrogen atoms from the ligand and one oxygen atom from the other ligand coordinate to each copper(II) center. Both the copper(II) centers in a dinuclear unit are penta-coordinate with a slightly distorted square pyramidal geometry. The IR spectra of mono-and dinuclear copper(II) complexes have different bands. The absorption spectra of mono-and di-nuclear complexes are quite similar in methanol solvent. However, the electronic absorption spectra of the two complexes are basically different in the solid state.

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Section: Description Of Crystal Structure Of the Complexsupporting

confidence: 63%

Synthesis and Structural Characterization of a Double Helical Dinuclear Copper(II) Complex With Tetradentate Biacetyl Bis(benzoylhydrazone)

Vafazadeh

Abdollahi²,

Willis³

2017

ACSi

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“…A classical intercalation binding requires the space of adjacent base pairs to be large enough to accommodate the bound small molecules and to elongate the double helix, resulting in an increase of ct-DNA viscosity [34]. In contrast, there is little effect on the viscosity of DNA if electrostatic or groove binding occurs [35]. …”

Section: Viscosity Measurementsmentioning

confidence: 98%

Synthesis, characterization and comparative DNA interaction studies of new copper(II) and nickel(II) complexes containing mesalamine drug using molecular modeling and multispectroscopic methods

Shahabadi

Fili

Shahlaei

2015

Journal of Coordination Chemistry

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Complexes of copper(II) and nickel(II) containing the drug mesalamine (5-ASA) have been synthesized and characterized by FT-IR, mass and UV-vis spectra, elemental analysis and theoretical methods. The binding interactions between mesalamine and its Cu(II) and Ni(II) complexes with calf thymus DNA (ct-DNA) were investigated using absorption, fluorescence emission and circular dichroism spectroscopies, and viscosity measurements. Absorption spectra of 5-ASA, Cu(II) and Ni(II) complexes showed hypochromism. The calculated binding constants (K b ) obtained from UV-vis absorption studies were 1.27×10 3 , 1.6×10 3 and 1.2×10 4 M -1 for 5-ASA, Cu(II) and Ni(II) complexes, respectively. The compounds induced detectable changes in the CD spectra of ct-DNA (B→A structural transition, B→C structural transition and stabilization of the right-handed B form, for mesalamine, Cu(II) and Ni(II) complexes, respectively). The competitive binding experiments with Hoechst 33258 indicated that 5-ASA and copper complex could interact as groove binders. Furthermore, Ni complex had no effect on the fluorescence intensity and peak position of MB-DNA system. Finally, the results obtained from experimental and molecular modeling showed that complexes bind to DNA via minor groove binding.

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“…The interaction of transition metal complexes with DNA continues to attract interest in relation to enzyme-DNA interaction and in the search for anticancer chemotherapeutic agents [29][30][31][32][33][34][35][36][37]. Transition metal complexes can bind to DNA via covalent and/or non-covalent interactions [29].…”

Section: Introductionmentioning

confidence: 99%

“…In view of above importance and in continuation of our research in the field of biologically active complexes [30][31][32][33], we herein report the syntheses, spectroscopic characterization and DNA binding studies of Mn(II), Co(II), Ni(II) and…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and DNA Binding Studies of (E)-1-((Pyridin-2-yl)methylidene) semicarbazide Mn(II), Co(II), Ni(II) and Cu(II) Complexes

U-wang

Singh

Devi

et al. 2019

CSIJ

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(E)-1-((pyridin-2-yl)methylidene)semicarbazide (PMSC) complexes of [Mn(PMSC)2 ]Cl2 (1), [Co(PMSC)2]Cl2 (2), [Ni(PMSC)2]Cl2.5H2O (3), and [Cu(PMSC)(H2O)]Cl2 (4) have been synthesized and characterized by different spectroscopic techniques, EPR, magnetic susceptibility and thermal stability measurements. Complex 3 crystallizes as octahedral coordination complex in monoclinic crystal system. Complexes 1 and 2 have been found to have octahedral geometries and 4 to have square planar geometry. The complexes were found to be groove binding to calf-thymus DNA.

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Synthesis, characterization, crystal structure, and DNA binding of two copper(II)–hydrazone complexes

Cited by 31 publications

References 53 publications

Synthesis and Structural Characterization of a Double Helical Dinuclear Copper(II) Complex With Tetradentate Biacetyl Bis(benzoylhydrazone)

Synthesis and Structural Characterization of a Double Helical Dinuclear Copper(II) Complex With Tetradentate Biacetyl Bis(benzoylhydrazone)

Synthesis, characterization and comparative DNA interaction studies of new copper(II) and nickel(II) complexes containing mesalamine drug using molecular modeling and multispectroscopic methods

Synthesis, Characterization and DNA Binding Studies of (E)-1-((Pyridin-2-yl)methylidene) semicarbazide Mn(II), Co(II), Ni(II) and Cu(II) Complexes

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