Synthesis, characterization, antioxidant properties and DFT calculation of some new pyrimidine derivatives

Synthesis of new thiazine and thiazole derivatives via cyclization reactions; investigating their electronic properties and determination of antioxidant properties

“…In the last step, the reactions of compound 3 with substituted benzaldehyde and 2-thiophene carboxaldehyde are carried out, benzylidene compounds linked to the thiazolo[3,2-a] pyrimidine skeleton (4-9) were obtained. All the compounds obtained are original and their spectroscopic results are in agreement with the literature data [7,22,23].…”

“…Cyclization reaction of compound 1 with halo carbonyl reagents can theoretically yield two regioisomers as linear and angular products. In our previous studies on these products, X‐ray analyses of similar compounds were performed [22]. Due to the tautomerization between N (1) atom and the benzoyl group in the pyrimidinthione compound (Scheme 2), it can be said that the linear form of the isomer will be formed [23].…”

Recent medicinal approaches of novel pyrimidine analogs: A review

“…Among all compounds ( 25 ) exhibited satisfactory anti-oxidant potency (IC 50 : 155.80 μm) compared with standard (Tocopherol, IC 50 :145.59 μm). The observed activity may be due to the presence of pyrimidine scaffold [ 29 ].…”

Theoretical calculation of newly synthesized tetrazolopyrimidine derivatives as a potential corrosion inhibitor

“…The physical, analytical, and spectral data for the compounds are given in the Supplementary Material to this paper. Synthesis (7-(4-(Methylthio)phenyl)-5-phenyl-4,7-dihydrotetrazolo[1,5-α]pyrimidin-6-yl)(phenyl) methanone (6) The mixture of (4-(4-(methylthio)phenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin--5-yl)(phenyl)methanone (1 mmol), 22 sodium azide (2 mmol) and mercuric acetate (1 mmol) in acetic acid (5 mL) was stirred at 100 °C for 6 h. After completion of the reaction (monitored by thin-layer chromatography), the black sediment (HgS) was filtrated. Then water was added to the filtrate to give the crude product.…”