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Pyridazine derivatives R 0500Antibacterial and Antifungal Activities of New Pyrazolo[3,4-d]pyridazin Derivatives. -A series of novel pyrazolo[3,4-d]pyridazines (V) and (IX) is synthesized and tested for their antimicrobial activities. Derivatives (Vd) and (Ve) display potent antibacterial and antifungal activities. -(AKBAS*, E.; BERBER, I.; Eur. J. Med. Chem. 40 (2005) 4, 401-405; Dep. Chem., Fac. Arts Sci., Yuezuencue Yil Univ., TR-65080 Van, Turk.; Eng.) -R. Staver 36-142

The inhibition effect of two pyrimidine derivatives on the corrosion of austenitic stainless steel in 1 M HCl has been studied by Tafel plot, linear polarization, and electrochemical impedance spectroscopy (EIS) at 298 K. Results showed that compounds inhibited steel corrosion in a 1 M HCl solution and inhibition efficiencies increased with the concentration of inhibitor. Polarization curves indicated that all studied pyrimidine derivatives act as mixed type (cathodic/anodic) inhibitors. The adsorption of the inhibitors on the stainless steel surface was found to obey the Langmuir and Dubinin–Radushkevich adsorption isotherm models. Negative values of ΔGads in the acidic media ensured the spontaneity of the adsorption process.

Context:Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds.Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar albino rats.Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10 mg/kg) for the first 7 days. FASB methanol extract (150 and 300 mg/kg) was administered orally for 21 days.Results: α-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of FASB were 0.70 ± 0.13, 0.29 ± 0.03 μg/g, 139.32 ± 7.06 μg/100 g, 171.61 ± 6.05 mM ascorbic acid/g, 90.47 ± 4.11 mg GA/g and 37.39 ± 2.85 mg QE/g. DPPH and hydroxyl radical scavenging activity was obtained IC50 67.34 ± 4.14 and 64.87 ± 4.68 μg/mL, respectively.Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that the plant could be used as a hepatoprotective.

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