Synthesis, characterization, antioxidant potential, and cytotoxicity screening of new Cu(II) complexes with 4-(arylchalcogenyl)-1H-pyrazoles ligands

Pinheiro, A. C.; Busatto, Franciele Faccio; Schaefer, Bruna T.; Tomasini, Paula Pellenz; Nunes, Ianka Jacondino; Machado, Tamara Dos S.; Cargnelutti, Roberta; Aquino, Thalita F.B. de; Ferreira, Kethlin De Q.; Casaril, Angela Maria; Jacob, Raquel G.; Savegnago, Lucielli; Hartwig, Daniela; Saffi, Jenifer

doi:10.1016/j.jinorgbio.2022.112013

Cited by 7 publications

(2 citation statements)

References 79 publications

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“…Pinheiro et al [78] have reported the synthesis, characterization, antioxidant potential, and cytotoxicity of a new Cu(II) complex 47, derived from 46a. The synthesis involved the slow addition of a solution of 46a (0.92 mmol) in MeOH to a solution of CuCl 2 •2H 2 O (0.46 mmol) in MeOH for 18 h at room temperature, obtaining the desired product in 80% yield (Scheme 20).…”

Section: Se-functionalized N-heterocyclesmentioning

confidence: 99%

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Anghinoni,

Birmann,

da Rocha

et al. 2023

Molecules

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Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

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Section: Se-functionalized N-heterocyclesmentioning

confidence: 99%

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Anghinoni,

Birmann,

da Rocha

et al. 2023

Molecules

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“…In this context, chalcogen–tetrazolo[1,5- a ]quinolines constitute an interesting class of molecules, which combine the importance of a tetrazoloquinoline nucleus [ 8 , 9 , 10 , 11 ] with an organochalcogen moiety [ 12 , 13 , 14 ]. Selenium and sulfur are important essential elements, playing important roles in metabolic pathways [ 15 , 16 , 17 , 18 , 19 , 20 ], and the interest in chalcogen chemistry [ 21 , 22 , 23 ] and pharmacology [ 24 , 25 , 26 , 27 ] has increased in this century.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 4-(Phenylchalcogenyl)tetrazolo[1,5-a]quinolines by Bicyclization of 2-Azidobenzaldehydes with Phenylchalcogenylacetonitrile

et al. 2023

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A general methodology to access valuable 4-(phenylchalcogenyl)tetrazolo[1,5-a]quinolines was developed by the reaction of 2-azidobenzaldehyde with phenylchalcogenylacetonitriles (sulfur and selenium) in the presence of potassium carbonate (20 mol%) as a catalyst. The reactions were conducted using a mixture of dimethylsulfoxide and water (7:3) as solvent at 80 °C for 4 h. This new methodology presents a good functional group tolerance to electron-deficient and electron-rich substituents, affording a total of twelve different 4-(phenylchalcogenyl)tetrazolo[1,5-a]quinolines selectively in moderate to excellent yields. The structure of the synthesized 4-(phenylselanyl)tetrazolo[1,5-a]quinoline was confirmed by X-ray analysis.

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Copper pyrazole complexes as potential anticancer agents: Evaluation of cytotoxic response against cancer cells and their mechanistic action at the molecular level

Ghorbanpour,

Shayanfar,

Soltani

2024

Coordination Chemistry Reviews

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Synthesis, characterization, antioxidant potential, and cytotoxicity screening of new Cu(II) complexes with 4-(arylchalcogenyl)-1H-pyrazoles ligands

Cited by 7 publications

References 79 publications

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Synthesis of 4-(Phenylchalcogenyl)tetrazolo[1,5-a]quinolines by Bicyclization of 2-Azidobenzaldehydes with Phenylchalcogenylacetonitrile

Copper pyrazole complexes as potential anticancer agents: Evaluation of cytotoxic response against cancer cells and their mechanistic action at the molecular level

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