2019
DOI: 10.1002/slct.201803294
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Synthesis, Characterization, Anticancer and Antimicrobial Activity Studies of Novel Isomeric 2,4‐Disubstituted Ureide Derivatives of Pyrimidinopiperidines

Abstract: A series of isomeric ureide derivatives of novel 2,4-disubstituted pyrimidinopiperidines were synthesized starting from 2,4dichloropyrimidine. All the final products were purified on silica and characterized by spectral analysis. Both the 2,4-disubstituted pyrimidinopiperidines were analyzed for their in vitro anticancer activity on the cell lines HCT116, MIA-PaCa2 and MDA-MB 231 by using MTT cell proliferation assay. Further, the antimicrobial studies were carried out against different bacterial and fungal st… Show more

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Cited by 4 publications
(2 citation statements)
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“…Very recently our group reported the synthesis and anticancer activity of N-methyl-3-arylindazole derivatives using Pd catalyst. 23 In continuation to our efforts in developing structurally diverse heterocyclic compounds as antimicrobial agents [24][25][26][27] herein, we report the antimicrobial activities of some N-methyl-3-arylindazoles (5a-5j).…”
Section: Introductionmentioning
confidence: 99%
“…Very recently our group reported the synthesis and anticancer activity of N-methyl-3-arylindazole derivatives using Pd catalyst. 23 In continuation to our efforts in developing structurally diverse heterocyclic compounds as antimicrobial agents [24][25][26][27] herein, we report the antimicrobial activities of some N-methyl-3-arylindazoles (5a-5j).…”
Section: Introductionmentioning
confidence: 99%
“…An excellent review on sulfones was presented very recently by Trost et al [39]. In view of this and as an extension to our search for novel antimicrobial agents [40][41][42][43][44], the authors herein made an attempt to synthesize the titled sulfones and screen their antimicrobial properties.…”
Section: Introductionmentioning
confidence: 99%