Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives

Evaluation of magnetically recyclable nano-Fe3O4 as a green catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono and bis 1,4-dihydropyridine derivatives

“…Particularly, bisheterocyclic compounds, which exhibit various biological activities, including antibacterial, fungicidal, tuberculostatic, and antiamoebic properties [10][11][12], play important roles in the drug discovery processes and analysis of drugs in late development.…”

Three-Component Synthesis of Mono and Bis 4,5-Dihydropyrano[3,2-C]Chromenes and 4,5- Dihydropyran[4,3-B]Pyrans Catalyzed by Sodium Benzenesulfinates as a Green Organocatalyst

“…10,11 In the recent years, a great deal of research into PFHC has permitted the synthesis of bisheterocyclic compounds that show various biological activities, such as antibacterial, fungicidal, tuberculostatic, and antiamoebic properties. [12][13][14] Among these aforementioned compounds, 4,5-dihydropyrano [3,2-c]chromene and 4,5-dihydropyrano [4,3-b]pyran derivatives have received much attention, due to their remarkable molecular structures and important biological 15 and pharmacological 16 applications. Therefore, considerable attention has been focused on the development of environmentally friendly procedures to synthesize dihydropyranochromene and dihydropyranopyran derivatives, by three-component reaction of aromatic aldehydes, malononitrile and 4-hydroxycoumarin or 4-hydroxy-6-methylpyrone.…”

Synthesis, Reactions and Characterization of 1,1’-(1,4-Phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(ethan-1-one)

“…In fact, the synthesis of bis-heterocyclic compounds exhibits various biological activities [1]- [8] including antibacterial, fungicidal, tuberculostatic, antiamoebic, and plant growth regulative properties. Also, bis-compounds have received great attention [9] [10] not only for being model compounds for main chain polymers [11]- [16] but also because many biologically active natural and synthetic products have molecular symmetry [17].…”