Synthesis, Characterization, and Properties of Some Copper(<scp>II</scp>) Complexes of 2‐Pyridineformamide Thiosemicarbazone (HAm4DH)

Aguirre, María del Carmen; Borrás, Joaquı́n; Castiñeiras, Alfonso; García‐Monteagudo, José M.; García‐Santos, Isabel; Niclós, Juan; West, Douglas X.

doi:10.1002/ejic.200500792

Cited by 31 publications

(2 citation statements)

References 48 publications

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“…The ligands were synthesized according to a procedure reported previously. 37,38 2-Cyanopyridine was dissolved in sodium methoxide solution under stirring for 0.5 h. The thiosemicarbazide was added in small portions to the above solution, the mixture was then reuxed for another 4 h. The pale yellow solution was cooled to room temperature and ltered, aer that, the yellowish precipitation was dissolved and recrystallized from methanol. The product and several drops of triethylamine were mixed in toluene solvent, aer stirring 10 min, 1.2 equivalent of chloroacetic acid was added.…”

Section: Preparation Of 13-thiazolidin-4-ones (Ligands)mentioning

confidence: 99%

Novel Zn(ii)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene

Lin

Peng

et al. 2016

RSC Adv.

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Section: Preparation Of 13-thiazolidin-4-ones (Ligands)mentioning

confidence: 99%

Novel Zn(ii)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene

Lin

Peng

et al. 2016

RSC Adv.

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“…In addition, dinuclear complexes containing the neutral HL form of the ligand seem to exhibit lower antiferromagnetic interactions than the analogous with deprotonated L − form. Magnetic interactions have been reported for other thiosemicar-bazonecopper(II) systems and evidence a majority antiferromagnetic behavior [42][43][44][45][46][47], as those described for non-thiosemicarbazone systems [48][49][50].…”

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confidence: 62%

Thiosemicarbazonecopper/Halido Systems: Structure and DFT Analysis of the Magnetic Coupling

et al. 2023

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Experimental magnetic studies performed on the [{CuLX}2] system (HL = pyridine-2-carbaldehyde thiosemicarbazone, X = Cl−, Br−, I−) point to the larger electronegativity in X, the lower magnitude of the antiferromagnetic interactions. In order to confirm this and other trends observed and to dip into them, computational studies on the [{CuLX}2] (X = Cl− (1), I− (2)) compounds are here reported. The chemical and structural comparisons have been extended to the compounds obtained in acid medium. In this regard, chlorido ligands yield the [Cu(HL)Cl2]∙H2O (3) complex, whose crystal structure shows that thiosemicarbazone links as a tridentate chelate ligand to square pyramidal Cu(II) ions. On the other hand, iodido ligands provoke the formation of the [{Cu(H2L)I2}2] (4) derivative, which contains pyridine-protonated cationic H2L+ as a S-donor monodentate ligand bonded to Cu(I) ions. Crystallographic, infrared and electron paramagnetic resonance spectroscopic results are discussed. Computational calculations predict a greater stability for the chlorido species, containing both the neutral (HL) and anionic (L−) ligand. The theoretical magnetic studies considering isolated dimeric entities reproduce the sign and magnitude of the antiferromagnetism in 1, but no good agreement is found for compound 2. The sensitivity to the basis set and the presence of interdimer magnetic interactions are debated.

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Novel 2‐formylpyridine 4‐allyl‐S‐methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity

Bălan

Burduniuc

Usataia

et al. 2019

Applied Organom Chemis

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New zinc (II), copper (II), nickel (II) and cobalt (III) complexes, [Zn (HL)2]I2 (1), [Cu (HL)Cl2] (2), [Cu (HL)Br2] (3), [Cu (HL)(H2O)2](ClO4)2 (4), [Ni (HL)2]I2·H2O (5), [Co(L)2]Cl (6), [Co(L)2]NO3 (7), [Co(L)2]I·[Co(L)2](I3) (8) were obtained with 2‐formylpyridine 4‐allyl‐S‐methylisothiosemicarbazone (HL). The isothiosemicarbazone ligand was characterized by NMR (1H and 13C), IR spectroscopy and X‐ray diffraction. All the complexes were characterized by elemental analysis, IR, UV–Vis, ESI‐MS spectroscopy, molar conductivity, magnetic susceptibility measurements. X‐ray diffraction analysis on the monocrystal and powder elucidated the structure of the complexes 1, 5, 7 and 8. The ligand and the complexes were tested for their antioxidant and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans. Also, the antiproliferative properties of these compounds on human leukemia HL‐60, human cervical epithelial HeLa, human epithelial pancreatic adenocarcinoma BxPC‐3, human muscle rhabdomyosarcoma spindle, large multinucleated RD cells and normal MDCK cells have been investigated. The nickel complex 5 and cobalt complexes 6, 7 showed promising antiproliferative activity and low toxicity.

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Synthesis, Characterization, and Properties of Some Copper(II) Complexes of 2‐Pyridineformamide Thiosemicarbazone (HAm4DH)

Cited by 31 publications

References 48 publications

Novel Zn(ii)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene

Novel Zn(ii)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene

Thiosemicarbazonecopper/Halido Systems: Structure and DFT Analysis of the Magnetic Coupling

Novel 2‐formylpyridine 4‐allyl‐S‐methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity

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