Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides

Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides.

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Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

Park

Yoon

2019

Journal of Industrial Microbiology and Biotechnology

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Ahire

Robertson

Reenen

et al. 2017

Biomedicine & Pharmacotherapy

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Wang,

Liu

et al. 2024

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Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides

Cited by 6 publications

References 45 publications

Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

Polyethylene oxide (PEO)-hyaluronic acid (HA) nanofibers with kanamycin inhibits the growth of Listeria monocytogenes

An antibacterial nanoclay- and chitosan-based quad composite with controlled drug release for infected skin wound healing

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