Polyethylene oxide (PEO)-hyaluronic acid (HA) nanofibers with kanamycin inhibits the growth of Listeria monocytogenes

Ahire, Jayesh J.; Robertson, Divann; Reenen, Albert J. van; Dicks, Leon M. T.

doi:10.1016/j.biopha.2016.12.006

Cited by 55 publications

(25 citation statements)

References 31 publications

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“…The next method helping to fabricate hyaluronan-based fibers is the utilizing of water-soluble modifying polymers named carrying polymers. The most usable polymer is polyethylene oxide (PEO) [64,65]. In the first case, 50 wt% aqueous acetic acid was utilized as a solvent that could result in hyaluronan depolymerization.…”

Section: Electrospinningmentioning

confidence: 99%

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

et al. 2019

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Nano- and microfibers based on biopolymers are some of the most attractive issues of biotechnology due to their unique properties and effectiveness. Hyaluronan is well-known as a biodegradable, naturally-occurring polymer, which has great potential for being utilized in a fibrous form. The obtaining of fibers from hyaluronan presents a major challenge because of the hydrophilic character of the polymer and the high viscosity level of its solutions. Electrospinning, as the advanced and effective method of the fiber generation, is difficult. The nano- and microfibers from hyaluronan may be obtained by utilizing special techniques, including binary/ternary solvent systems and several polymers described as modifying (or carrying), such as polyethylene oxide (PEO) and polyvinyl alcohol (PVA). This paper reviews various methods for the synthesis of hyaluronan-based fibers, and also collects brief information on the properties and biological activity of hyaluronan and fibrous materials based on it.

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Section: Electrospinningmentioning

confidence: 99%

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

et al. 2019

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“…The former nanofibers exhibited good hemocompatibility and cytocompatibility, with the ability to arrest CD44 receptor-overexpressing cancer cells. Ahire et al, (2016) [246] prepared PEO nanofibers, containing kanamycin and HA by electrospinning for inhibition of growth of Listeria monocytogenes, which causes joint infections. The solutions were prepared in DI water and electrospinning was conducted at +10 kV applied to the polymer dispensing die and −5 kV at the collector.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

A Review on Biopolymer-Based Fibers via Electrospinning and Solution Blowing and Their Applications

Kakoria

Sinha-Ray

2018

Fibers

128

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Electrospinning, for the last few decades, has been extensively acknowledged for its ability to manufacture a macro/nanofibrous architecture from biopolymers, which is otherwise difficult to obtain, in a cost effective and user-friendly technique. Such biopolymer nanofibers can be tailored to meet applications such as drug delivery, tissue engineering, filtration, fuel cell, and food packaging etc. Due to their structural uniqueness, chemical and mechanical stability, functionality, super-high surface area-to-volume ratio, and one-dimensional orientation, electrospun biopolymer nanofibers have been proven to be extremely beneficial. A parallel method in nonwoven methodologies called "Solution Blowing" has also become a potential candidate to fabricate a similar type of architecture from biopolymer fibers, and is gaining popularity among researchers, despite its recent advent in early 2000's. This review chiefly focuses on the fabrication of biopolymer macro/nanofibers via electrospinning and solution blowing, and several applications of such fiber architectures. Biopolymers include plant-and animal-derived biopolymers, such as cellulose, lignin, chitin, and chitosan, as well as proteins and their derivatives. The fabrication of biopolymer fibers from these biopolymers alone or as blends, predominantly with biodegradable polymers like Polyvinyl alcohol (PVA), Polyethylene Oxide (PEO), Polyethylene glycol (PEG), poly (lactide-co-glycolide) (PLGA) etc., or non-biodegradable polymers like polyamide, Polyacrylonitrile (PAN) etc., will be discussed in detail, along with the applications of several composites of such sort.

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“…The nanofibrous structure closely mimics the structure of the native extracellular matrix (ECM) in which cells normally reside in the body [ 1 , 2 ]. To ensure the growth of cells, these supports must be porous, should have good water-holding capacity, and should allow easy permeation of gases and metabolites.…”

Section: Introductionmentioning

confidence: 99%

“…Electrospinning of soluble polymers at high voltage is a simple technique to produce micro- to nanoscale nanofibers. The large area to volume ratio and high porosity of electrospun fibers promotes the adhesion of cells and cell growth [ 2 ]. This technique was previously used in our laboratory to produce pure and stable chitosan fibers [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Hyaluronan (HA), also called hyaluronic acid, is a natural polysaccharide and a critical component of natural ECM being widely used in tissue engineering and regenerative medicine [ 2 , 8 , 9 , 10 , 11 ]. These authors produced HA fibers using dimethylformamide (DMF)/water mixed solvents in different volume ratios (0:1, 0.25:1, 0.5:1, and 1:1, respectively) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Production of Chitosan/Hyaluronan Complex Nanofibers. Characterization and Physical Properties as a Function of the Composition

et al. 2020

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In this work, optimized conditions for preparation of chitosan and hyaluronan polyelectrolyte complex are proposed. The objective was to produce new biomaterials being biocompatible and bioresorbable in the body as well as approaching the extracellular matrix (ECM) structure. These materials will be tested for chondrocyte development in tissue engineering and wound healing applications. Nanofibers made of the polyelectrolyte complex (PEC) were successfully manufactured by electrospinning, and casted films were used as a model for properties comparison. To our knowledge, it is the first time that stable chitosan/hyaluronan fibers are produced, which were observed to be long-lasting in buffer at pH~7.4. The role of thermal treatment at 120 °C for 4 h is examined to control the degree of swelling by crosslinking of the two polysaccharides by H-bonds and amide bonds formation. The properties of the materials are tested for different PEC compositions at different pH values, based on swelling and solubility degrees, diameters of nanofibers and mechanical performances. The influence of the solvent (acidic potential and composition) utilized to process biomaterials is also examined. Acid formic/water 50/50 v/v is observed to be the more appropriated solvent for the carried-out procedures.

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Polyethylene oxide (PEO)-hyaluronic acid (HA) nanofibers with kanamycin inhibits the growth of Listeria monocytogenes

Cited by 55 publications

References 31 publications

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

A Review on Biopolymer-Based Fibers via Electrospinning and Solution Blowing and Their Applications

Production of Chitosan/Hyaluronan Complex Nanofibers. Characterization and Physical Properties as a Function of the Composition

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