Synthesis, Characterization and In Vitro Cytotoxicity of Poly[(5-benzyloxy-trimethylene carbonate)-co-(trimethylene carbonate)]

Wang, Xu Li; Zhuo, Ren Xi; Huang, Shi Wen; Liu, Li Jian; He, Feng

doi:10.1002/1521-3935(20020401)203:7<985::aid-macp985>3.0.co;2-0

Cited by 19 publications

(12 citation statements)

References 5 publications

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“…For random copolymers, Fox derived the following equation that allows the estimation of the T g of a copolymer on the basis of the T g 's of the respective homopolymer15, 31 Here, W 1 and W 2 refer to the weight fractions of the two comonomers and T g1 and T g2 refer to the T g 's of the two corresponding homopolymers. A plot of T g versus W 2 (tri‐MC content) is depicted in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Studies on aliphatic polycarbonates with different substituents are interesting because the substituents at pendant could be used to tailor the thermal and physical mechanical properties of the corresponding polycarbonates 14, 15. A number of aliphatic polycarbonates with a variety of pendant groups have been reported for these purposes 16–19.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stenting for spontaneous left internal mammary artery dissection: A case report

Ziaee

Puri

Kern

2003

Cathet Cardio Intervent

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stenting for spontaneous left internal mammary artery dissection: A case report

Ziaee

Puri

Kern

2003

Cathet Cardio Intervent

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“…Although there is no acid degradation product during the degradation of PTMC [ 7 ], it lacks functional groups to link bioactive primitives. Therefore, 5-benzyloxy-trimethylene carbonate (BTMC) had been selected as the cyclic monomer to form polycarbonate copolymers containing hydroxyl groups [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Self-Assembly, and Drug-Release Properties of New Amphipathic Liquid Crystal Polycarbonates

Xie

Liu

et al. 2018

Nanomaterials

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New amphiphilic liquid crystal (LC) polycarbonate block copolymers containing side-chain cholesteryl units were synthesized. Their structure, thermal stability, and LC phase behavior were characterized with Fourier transform infrared (FT-IR) spectrum, 1H NMR, gel permeation chromatographic (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), polarizing optical microscope (POM), and XRD methods. The results demonstrated that the LC copolymers showed a double molecular arrangement of a smectic A phase at room temperature. With the elevating of LC unit content in such LC copolymers, the corresponding properties including decomposition temperature (Td), glass temperature (Tg), and isotropic temperature (Ti) increased. The LC copolymers showed pH-responsive self-assembly behavior under the weakly acidic condition, and with more side-chain LC units, the self-assembly process was faster, and the formed particle size was smaller. It indicated that the self-assembly driving force was derived from the orientational ability of LC. The particle size and morphologies of self-assembled microspheres loaded with doxorubicin (DOX), together with drug release tracking, were evaluated by dynamic light scattering (DLS), SEM, and UV–vis spectroscopy. The results showed that DOX could be quickly released in a weakly acidic environment due to the pH response of the self-assembled microspheres. This would offer a new strategy for drug delivery in clinic applications.

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“…The copolymers of BTMC and lactones could be functionalized with hydroxyl pendant groups to increase hydrophilicity. The copolymerizations of BTMC with lactones such as 1,4‐dioxan‐2‐one,14 glycolide,15 lactide,16 and other carbonates monomers17, 18 were intensively studied. Recently, a communication reported the copolymer of BTMC and CL with low molecular weight, so the copolymer was only fabricated into nanoparticles for drug delivery 19.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of functionalizable and biodegradable polymers via ring‐opening polymerization of 5‐benzyloxy‐trimethylene carbonate and ε‐caprolactone

Lai¹,

Ji²,

Long³

et al. 2011

J of Applied Polymer Sci

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The biomedical applications of poly(e-caprolactone) (PCL) were limited for its high hydrophobicity and crystallinity. In this study, we copolymerized CL with amorphous 5-hydroxyl-trimethylene carbonate (HTMC) to solve the problem. The 5-benzyloxy-trimethylene carbonate (BTMC) was synthesized to copolymerize with CL, then hydrogenolyzed to obtain hydroxyl pendant groups. A serial of copolymers with different BTMC molar ratio were synthesized and their chemical structures and thermal properties were thoroughly studied with NMR, FT-IR, GPC, XRD, DSC, and TGA. Finally we examined the water contact angle of the copolymers. DSC and XRD results showed that the PCL segments in the copolymers crystallized below 16.8%. BTMC molar content and the crystallinity of the copolymers increased after hydrolysis. With the introduced hydroxyl pendant groups, the deprotected copolymers improved their hydrophilic property significantly, and the copolymer with 9.3% HTMC molar content had static water contact angle as low as 36.5 .

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Synthesis, Characterization and In Vitro Cytotoxicity of Poly[(5-benzyloxy-trimethylene carbonate)-co-(trimethylene carbonate)]

Cited by 19 publications

References 5 publications

Stenting for spontaneous left internal mammary artery dissection: A case report

Stenting for spontaneous left internal mammary artery dissection: A case report

Synthesis, Self-Assembly, and Drug-Release Properties of New Amphipathic Liquid Crystal Polycarbonates

Synthesis of functionalizable and biodegradable polymers via ring‐opening polymerization of 5‐benzyloxy‐trimethylene carbonate and ε‐caprolactone

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