The biomedical applications of poly(l-lactide) (PLLA) were limited by its high crystallinity. In this paper, the copolymerization of trimethylene carbonate (TMC) and l-lactide (LLA) was carried out to improve the flexibility of PLLA. The effects of feeding dose, reaction temperature and polymerization time were investigated, and the copolymers were characterized with (1)H nuclear magnetic resonance, Fourier transform infrared reflection, gel permeation chromatography differential scanning calorimetry, thermogravimetric analysis and x-ray diffraction. The copolymers were electrospun to form porous films to study their cell compatibility. The results showed that the composition of the copolymer was nearly the same as that in the feeding dose, and the molecular weight of the copolymer decreased with increasing TMC content. The decrease in the reaction temperature and polymerization time would increase the molecular weight, but the composition deviates from the feeding dose. NIH/3T3 mouse fibroblast cells were cultured on the electrospun films. The morphology and proliferation of the cells were studied. The results implied that the cell compatibility of poly(l-lactide-co-trimethylene carbonate) copolymer was much better than that of the PLLA homopolymer.
The biomedical applications of poly(e-caprolactone) (PCL) were limited for its high hydrophobicity and crystallinity. In this study, we copolymerized CL with amorphous 5-hydroxyl-trimethylene carbonate (HTMC) to solve the problem. The 5-benzyloxy-trimethylene carbonate (BTMC) was synthesized to copolymerize with CL, then hydrogenolyzed to obtain hydroxyl pendant groups. A serial of copolymers with different BTMC molar ratio were synthesized and their chemical structures and thermal properties were thoroughly studied with NMR, FT-IR, GPC, XRD, DSC, and TGA. Finally we examined the water contact angle of the copolymers. DSC and XRD results showed that the PCL segments in the copolymers crystallized below 16.8%. BTMC molar content and the crystallinity of the copolymers increased after hydrolysis. With the introduced hydroxyl pendant groups, the deprotected copolymers improved their hydrophilic property significantly, and the copolymer with 9.3% HTMC molar content had static water contact angle as low as 36.5 .
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