Synthesis, Characterization andIn VitroAnticancer Evaluation of Itaconic Acid Based Random Copolyester

Abstract

The present study deals with the synthesis and characterization of an aliphatic copolyester, poly [butylene fumarate-co-butylene itaconate] (PIFB) copolymer was obtained from itaconic acid, fumaric acid, and 1,4-butanediol using titanium tetraisopropoxide (TTiPO) through a two step process of transesterification and melt polycondensation. The synthesized aliphatic random copolyester was characterized with the help of FT-IR,1H-NMR,13C-NMR, viscosity measurements, Gel Permeation Chromatography (GPC) and X-ray diffraction (XRD) analysis. Thermal properties have been analyzed using thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC). Hydrolytic degradation studies were carried out in acid and alkaline regions of various pH values. The synthesized copolymer was subjected toin vitroanticancer activity studies against human breast cancer (MCF-7) cell line.

Research progress on bio‐based thermosetting resins

“…Itaconic acid has two carboxyl groups and one carbon–carbon double bond in its molecular structure, which makes it very similar to maleic acid. Therefore, as a potential alternative to maleic acid and maleic anhydride, itaconic acid has been used to synthesize bio‐based UPEs . Through the condensation reaction between 1,4‐butanediol, succinic acid and itaconic acid or maleic acid, reactive carbon–carbon double bonds were introduced into the main chain of poly(butylene succinate) prepolymers .…”

Synthesis of Unsaturated Polyester Resins from Various Bio-Derived Platform Molecules

“…Unsaturated polyesters (UPEs) are a large family of polymers with a wide range of applications stemming from their ability to undergo various post-polymerisation reactions. They can be utilised in high-gloss coatings [ 1 ], insulating materials [ 1 ], drug delivery systems [ 2 ] and biomedical applications such as tissue engineering [ 2 ]. The polymer industry currently relies heavily on petroleum-based feedstocks [ 3 ] but with fossil fuel resources due to be soon depleted [ 4 ], biomass sources are of increasing interest in this research area [ 3 ].…”

Aza‐Michael addition reaction: Post‐polymerization modification and preparation of PEI/PEG‐based polyester hydrogels from enzymatically synthesized reactive polymers

“…In order to render the backbone sensitive toward amine nucleophiles, itaconate monomer 2 featuring an electron‐deficient alkene was selected as the co‐monomer. Itaconate‐based monomers can be obtained from natural resources and are shown to be useful building blocks in the preparation of a variety of biomaterials . A Candida antarctica lipase B catalyzed polyesterification between monomers 1 and 2 gave rise to the targeted PEG‐based polyester 3 carrying aza‐Michael acceptors placed along the polymer backbone .…”

“…Itaconate-based monomers can be obtained from natural resources and are shown to be useful building blocks in the preparation of a variety of biomaterials. [30][31][32][33][34][35] A Candida SCHEME 1 Synthesis of a polymeric aza-Michael acceptor scaffold and its modifications with small molecular aza-Michael donor amines. SCHEME 2 Hydrogel synthesis through polymer-polymer chain coupling between aza-Michael acceptor polyester and aza-Michael donor PEI.…”