Synthesis, characterization and evaluation of antifungal activity of seven-membered heterocycles

Abstract

This research includes synthesis of new heterocyclic derivatives of disubstituted 1,3-oxazepine-5-one. Azomethine compounds (N1-N5) were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as a catalyst in absolute ethanol. The synthesized compounds were identified via spectral methods viz., FT-IR, 1H-NMR, and 13C-NMR and measurements of some physical properties. The prepared oxazepine compounds (N6-N10) were obtained from treatment of azomethine compounds with phthalide. N9 and N7 derivatives have recorded the higher zone of inhibition 15 mm against Candida guilliermondii and Candida zeylanoides respectively. The lower zone of inhibition was 8.0 mm and 9.3 mm by N7 toward the growth of Candida albicans and Candida guilliermondii respectively. Slight variation in the structure of those derivatives can show the very dramatic effect on the efficiency of these compounds in their bio-activity and may be helpful in designing more antifungal agents for therapeutic use in future.

Synthesis, characterization and evaluation of the anti-cancer activity of silver nanoparticles by natural organic compounds extracted from cyperus sp. rhizomes

“…Histogram of the distribution of the two AgNPs was presented in Figure 4 was clear evidence for the forma particles by the percentages of Ag particles in the two treatments. All sizes of the biosynthe in the colloids are lesser than 100 nm which is considered a definite proof for the formati The absorption bands at 2891 cm -1 and 2894 cm -1 for cold and hot extracts respectively, and at 293 1 for cold and hot extracts also belong to vibrations of homogeneous and heterogeneous stretchin methylene group (-CH2) or a methyl group (-CH3) 36 . The spectra showed absorption bands at 163 1 and 1633 cm -1 for cold and hot extracts respectively go back to vibrations of stretching of C=C belongs to the alkene compounds and the successive double bonds in the benzene ring in the aro structures 37 .…”

“…The bands at 3267-3271 cm -1 and 3417-3367 indicate for the presence of the amine group (-NH2) in the synthesis of amino acids, peptides and pr for cold and hot extracts respectively 32,39 . The presence of the carboxylic group in amino acids, pe The absorption bands at 2891 cm -1 and 2894 cm -1 for cold and hot extracts respectively, and at 1 for cold and hot extracts also belong to vibrations of homogeneous and heterogeneous stret methylene group (-CH2) or a methyl group (-CH3) 36 . The spectra showed absorption bands at 1 and 1633 cm -1 for cold and hot extracts respectively go back to vibrations of stretching of C belongs to the alkene compounds and the successive double bonds in the benzene ring in the structures 37 .…”

“…The bands at 3267-3271 cm -1 and 3417-3 indicate for the presence of the amine group (-NH2) in the synthesis of amino acids, peptides an for cold and hot extracts respectively 32,39 . The presence of the carboxylic group in amino acids -1 The absorption bands at 2891 cm -1 and 2894 cm -1 for cold and hot extracts respectively, and at 2935 cm -1 for cold and hot extracts also belong to vibrations of homogeneous and heterogeneous stretching of a methylene group (-CH 2 ) or a methyl group (-CH 3 ) 36 . This research includes synthesis of new heterocyclic derivatives of disubstituted 1,3-oxazepine-5-one.…”

Synthesis and characterization of novel tetrazole derivatives and evaluation of their anti-candidal activity

“…Imine compounds (Scheme 6) were synthesized from commercially available aromatic aldehydes and primary amines and identified by their melting points, and FT-IR. The FT-IR spectra showed the appearance of the stretching absorption bands of azomethine (C=N) at 1591-1669 cm -1 , 27,28 beside the characteristic bands of the residual groups in the structure Table 3. See Figs.…”

Synthesis and Characterization of New Complexes for (1e,1'e)-N,n'-(Thiobis (4,1-Phenylene)) Bis(1-Phenylmethanimine) Substituted Ligands With Fe3+

“…Schiff bases are regarded as a very important class of organic compounds with a wide range of biological applications (1,2) . They include as a functional group azomethine (C= N) and therefore act as an effective ligand.…”