Synthesis and characterization of novel tetrazole derivatives and evaluation of their anti-candidal activity

Abstract

This research includes synthesis of new heterocycles containing disubstituted Tetrazole derivatives. Imine compounds were synthesized by reaction of primary aromatic amines with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new imine compounds O 1-O 5. The novel five-membered heterocycles as Tetrazole derivatives O 6-O 10 were obtained from treatment of each new imine compounds with sodium azide compound. Newly synthesized compounds were identified via spectral methods (FT-IR, 1 H-NMR and 13 C-NMR) spectra and some physical properties. O 6 is the best derivative that has significantly (p<0.01) recorded a stronger influence to inhibit the growth of Candida guilliermondii at an average of the zone of inhibition 14.0 mm. While, O 9 derivative recorded the lowest zone of inhibition 7.3 mm toward the same clinical fungal pathogen. The present work may be helpful in designing more potential antibacterial and antifungal agents for therapeutic use in the future.

Synthesis, Characterization of New Phenylene Bis Tetrazole and Bis Benzoxazepinedione Derivatives from some Bis Imines with its Biological Activity Assessment.

“…The addition of sodium azide to the bisimines resulting in forming bistetrazoles (T1-3), while in the case of phthalic anhydride addition, bisbenzoxazepinediones (B1-3) leading to be produced. For details about the mechanisms for synthesis of the bisimines, the bisbenzoxazepinediones and the bistetrazoles, see [15], [17] respectively.…”

Synthesizes, characterization, molecular modelling studies and bioactivity of a novel bicyclic compound of δ-lactam with oxazepine ring containing-sulphur substitute using an economic method

“…For example, 5 and 6-lactam ring contain similar functional group to β-lactam but with different number of carbons in the ring. Delta δ-lactam (6-membered ring) is a hexa-heterocyclic amide containing nitrogen atom next to carbonyl group [7,8]. The only difference is the number of the carbon atom in the ring which could show a difference bioactivity δ-lactam is a subgroup of lactam family that widely used in and medicine and pharmaceutical chemistry [9].…”

Preparation of some metallic complexes from selected organic ligands and characterization it spectrophotometry as a model of a ligand scavenger to metals in health applications

“…Imines compounds are containing the group (C=N) and they are preparing by the reaction between primary aromatic amines with aromatic aldehydes [1]. See scheme 1.…”