Synthesis, characterization and DFT study of new water-soluble aluminum(III), gallium(III) and indium(III) Schiff base complexes: effect of metal on the binding propensity with bovine serum albumin in water

Asadi, Zahra; Asadi, Mozaffar; Shorkaei, Mohammad Ranjkesh

doi:10.1007/s13738-015-0751-4

Cited by 18 publications

(13 citation statements)

References 38 publications

(36 reference statements)

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“…Correlation of the thermal events at elevated temperatures with kinetic parameters provides useful physicochemical information of the compounds. Thermo gravimetric analysis is one such important instrumental technique to observe thermal changes with respect to increase in temperatures [36]. The computed thermal decomposition data in Table 1 are in good agreement with the suggested microanalytical data.…”

Section: Resultssupporting

confidence: 69%

Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

Chaudhary

Mishra

2017

Bioinorganic Chemistry and Applications

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A novel Schiff base ligand of type HL was prepared by the condensation of amoxicillin trihydrate and nicotinaldehyde. The metal complexes of Co+2, Ni+2, Cu+2, and Zn+2 were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, SEM, and mass spectrometry measurements. They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. Thermal data revealed high thermal stability and nonspontaneous nature of the decomposition steps. The Coats-Redfern method was applied to extract thermodynamic parameters to explain the kinetic behavior. The molar conductance values were relatively low, showing their nonelectrolytic nature. The powder XRD pattern revealed amorphous nature except copper complex (1c) that crystallized in the triclinic crystal system. The EPR study strongly recommends the tetrahedral geometry of 1c. The structure optimization by MM force field calculation through ArgusLab 4.0.1 software program supports the concerned geometry of the complexes. The in vitro antibacterial activity of all the compounds, at their two different concentrations, was screened against four bacterial pathogens, namely, E. coli, P. vulgaris, K. pneumoniae, and S. aureus, and showed better activity compared to parent drug and control drug.

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Section: Resultssupporting

confidence: 69%

Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

Chaudhary

Mishra

2017

Bioinorganic Chemistry and Applications

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“…This is supported by the appearance a peak at 659 cm −1 in the metal complexes due to ν(C-S) (33) . The third feature is that the appearance of broad band at 3401cm −1 which can be assigned to the stretching frequencies of ν(OH) of water molecules either in the coordinated or uncoordinated form associated to the complexes which are also confirmed by thermal analyses as well as appearance of the non-ligand band at 554 cm −1 assignable to ν(M-O) (34,35) .…”

Section: Synthesis and Characterization Of Triazole Derivatives And Nmentioning

confidence: 75%

Synthesis and Evaluate of Some New 1,2,4-Triazoles to Modify Epoxy Resins in the Field of Anti-Microbial and Anti-Corrosive Organic Coating.

Khalik.¹

2017

IJAR

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“…Thus, in the presence of ibuprofen, the binding constant was lower than the binding constant in the presence of [Cu(carmoisine) 2 (H 2 O) 2 ] (2.27 × 10 4 M −1 ) while a smaller influence in the presence of warfarin in the binding constant was occurred . The results meant that the binding constant for the ternary system [Cu(carmoisine) 2 (H 2 O) 2 ]–HSA–ibuprofen was the most different, indicating that ibuprofen hinders the formation of [Cu(carmoisine) 2 (H 2 O) 2 ]–HSA and can compete for the same binding site in the region of site II (subdomain IIIA) of HSA …”

Section: Resultsmentioning

confidence: 99%

Interaction studies of copper complex containing food additive carmoisine dye with human serum albumin (HSA): Spectroscopic investigations

et al. 2017

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In this study, the interaction between human serum albumin (HSA) and a copper complex of carmoisine dye; [Cu(carmoisine) (H O) ], was studied in vitro using multi-spectroscopic methods. It was found that the intrinsic fluorescence of HSA was quenched by the addition of the [Cu(carmoisine) (H O) ] complex and the quenching mechanism was considered as static quenching by formation of a [Cu(carmoisine) (H O) ]-HSA complex. The binding constant was about 10 M at room temperature. The values of the calculated thermodynamic parameters (ΔH < 0 and ΔS > 0) suggested that both hydrogen bonds and the hydrophobic interactions were involved in the binding process. The site marker competitive experiments revealed that the binding of [Cu(carmoisine) (H O) ] to HSA primarily occurred in subdomain IIIA (site II) of HSA. The results of circular dichroism (CD) and UV-vis spectroscopy showed that the micro-environment of amino acid residues and the conformation of HSA were changed after addition of the [Cu(carmoisine) (H O) ] complex. Finally, the binding of the [Cu(carmoisine) (H O) ] complex to HSA was modelled by a molecular docking method. Excellent agreement was obtained between the experimental and theoretical results with respect to the binding forces and binding constant.

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Synthesis, characterization and DFT study of new water-soluble aluminum(III), gallium(III) and indium(III) Schiff base complexes: effect of metal on the binding propensity with bovine serum albumin in water

Cited by 18 publications

References 38 publications

Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

Synthesis and Evaluate of Some New 1,2,4-Triazoles to Modify Epoxy Resins in the Field of Anti-Microbial and Anti-Corrosive Organic Coating.

Interaction studies of copper complex containing food additive carmoisine dye with human serum albumin (HSA): Spectroscopic investigations

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