Synthesis, characterization and deepening in the comprehension of the biological action mechanisms of a new nickel complex with antiproliferative activity

Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells

“…Cytotoxicity index (CI%) was calculated to following formula comparing to control: CI %=1-OD (optical density) treated wells / OD control wells × 100 *p<0,050; **p<0,001 leukemia cell lines in next study antogonistic previous study [44]. In latest study of same group, it was observed to induce an antiproliferative effect of new nickel complex on U937 cells at low concentrations (IC 50 =14.4 μM) [45]. The effective HCTs [α-(N)-heterocyclic carboxaldehyde thiosemicarbazones, e.g., 3-AP and 3-AMP were also assessed in L1210 leukemia cells and L1210 leukemia bearing mice in vivo by Li et.al.…”

Characterization and DNA-interaction studies of 1,1-dicyano-2,2-ethylene dithiolate Ni(II) mixed-ligand complexes with 2-amino-5-methyl thiazole, 2-amino-2-thiazoline and imidazole. Crystal structure of [Ni(i-MNT)(2a-5mt)2]

“…4 Some of the Ni(II) complexes with dimethyldithiophosphates ligands is reported to be active against Walker 256 carcinosarkoma tumor system, but they were found to be inactive against L1210 leukemia. 5 Regarding the DNA interaction with Ni(II) complexes showed intercalative behavior and also DNA cleavage ability. 6 In our previous studies a series of mixed-ligand Cu(II) coordination compounds, with bidentate, tridentate and polydentate amines and their Schiff bases, 7,8 trihalides, 9 1,2-dithiolates, 10 and 1,3-thiazoles, thiazolines and imidazole [11][12][13][14] have been utilized as models to investigate their toxicity, 10,12 anti-inflammatory activity, 12 antimicrobial activity against Gram(+) and Gram(À) bacteria 9,11,14 and anti-proliferative activity in vitro 9,11,13,14 and in vivo 10,12 towards various cancer cell lines, for example, HeLa, T47D, HT-29, MCF7, MRC5 and P388 leukemia.…”

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

“…[4][5][6][7][8][9][10][11][12][13][14][15][16] Hydrazone ligands create an environment similar to the one present in biological systems usually by making coordination through oxygen and nitrogen atoms. Various important properties of carbonic acid hydrazides, along with their applications in medicine and analytical chemistry, have led to increased interest in their complexation characteristics with transition metal ions.…”