Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarine-derived ligand

Ilić, Dragoslav; Jevtić, Verica V.; Arsikin, Katarina; Ristić, Biljana; Harhaji-Trajković, Ljubica; Vuković, Nenad; Sukdolak, Slobodan; Klisurić, Olivera R.; Trajkovič, Vladimir; Trifunović, Srećko R.

doi:10.1016/j.ejmech.2013.12.051

Cited by 32 publications

(11 citation statements)

References 17 publications

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“…In addition, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl]oxy coumarin showed potent cytotoxicity (IC 50 Besides, in LDH release test cytotoxic effect of PS was detected at dose of 320 mg/L (Tables 1-3). In parallel to our findings, increase in LDH release in mouse fibrosarcoma L929, human glioma U251 and mouse melanoma B16 cell lines were determined (34). In our study, the obtained results demonstrated that PS-7H4MC and PS-K 2 B 4 O 7 reduced LDH release by PS as % 6.1 and %10.8 respectively.…”

Section: Resultssupporting

confidence: 75%

“…Natural Science and Discovery 2016; 2(2): [26][27][28][29][30][31][32][33][34][35] According to the molecule chemical structure, different pharmacological properties are due to coumarin and derivatives, such as anti-microbial, anti-mutagenic, anti-parasitic, antioxidant and others (10)(11)(12)(13). Besides, coumarin has important anesthetic agent on animals in laboratory experiments due to little effect upon the circulation.…”

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confidence: 99%

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The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives

Akman

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Yazicı

et al. 2016

Natural Science and Discovery

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Section: Resultssupporting

confidence: 75%

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confidence: 99%

The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives

Akman

Çelikezen

Yazicı

et al. 2016

Natural Science and Discovery

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“…In comparison, platinum and palladium have a noteworthy similarity in terms of the coordination chemistry . Based on our literature review, palladium (II) complexes generally disclose a lower antitumor potential than cisplatin because they have a more labile nature in comparison to the corresponding platinum (II) complexes . Though, in 2004, some palladium (II) complexes synthesized by Budzisz et al.…”

Section: Introductionmentioning

confidence: 99%

Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol

et al. 2019

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New Pd(II) and Pt(II) complexes are described in which the multidentate phosphorus ylides [Ph2P(CH2)nPPh2=C(H)C(O)C6H4‐p‐OCH3] (n=1, (Y1); n=2, (Y2)) act as P,C chelating ligands. The chelating ability of these ligands resulted in the formation of [MBr2{K2(P,C)‐Y1}] (M=Pd (1), Pt (2)); [MBr2{K2(P,C)‐Y2}] (M=Pd (3), Pt (4) complexes, which were investigated using physicochemical techniques. X‐ray diffraction studies of a single crystal of complex 2 confirmed the structure of the five‐membered ring. Owing to the redox activity of phosphorus‐ylide complexes, their electrocatalytic activity for the oxidation of methanol has been studied. All compounds were found to possess the anti‐proliferative potency against MCF‐7 (breast carcinoma), A549 (non‐small lung carcinoma) and AGS (gastric carcinoma) cell lines with average IC50 values in the range of 14.53 to 287.92 μM. In general, the compounds Y1, Y2, 2, and 3 displayed high anticancer activities compared to 1 and 4. The antioxidant activity of the compounds, which was estimated by 1, 1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) free radical scavenging, was moderate to strong with IC50 values in the range 0.18 to 0.59 mg mL−1.

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“…In this regard, benzopyran based compounds, like chromones, may be regarded as privileged scaffolds for rational design of anti-cancer agents (20). Cytotoxic activity has been reported for several chromone derivatives such as 3-formylchromones (21), 2,3-diarylchromanones (22), 3-hydroxychromones (23), 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates (24), 3-(3-oxobenzofuran-2(3H)-ylidene)methyl)-4H-chromones (25) and also for organometallic complexes of chromone derivatives (26).…”

Section: Introductionmentioning

confidence: 99%

Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds

et al. 2019

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Cancer is a major cause of death worldwide and novel anticancer agents for its better management are much needed. Benzopyrone-based compounds, such as chromones, possess several distinctive chemical and biological properties, of which the cytotoxicity against cancer cells seems to be prominent. In this study, two series of compounds based on chromen-4-one (3-10) and chromane-2,4-dione (11-18) scaffolds were synthesized in moderate/high yields and evaluated for cytotoxicity against HL-60, MOLT-4, and MCF-7 cancer cells using MTT assay. In general, the compounds exhibited moderate cytotoxic effects against the cancer cell lines, among which, a superior potency could be observed against MOLT-4 cells. Chroman-2,4-dione (11-18) derivatives had overall higher potencies compared to their chromen-4-one (3-10) counterparts. Compound 13 displayed the lowest IC 50 values against HL-60 (IC 50 , 42.0 ± 2.7 μM) and MOLT-4 cell lines (IC 50 , 24.4 ± 2.6 μM), while derivative 11 showed the highest activity against MCF-7 cells (IC 50 , 68.4 ± 3.9 μM). In conclusion, this study provides important information on the cytotoxic effects of chromone derivatives. Benzochroman-2,4-dione has been identified as a promising scaffold, which its potency can be modulated by tailored synthesis with the aim of finding novel and dissimilar anticancer compounds.

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Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarine-derived ligand

Cited by 32 publications

References 17 publications

The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives

The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives

Pd(II) and Pt(II) Metallacycles with Unsymmetrical Ylide: Antiproliferative Effects and Application in Electrocatalytic Oxidation of Methanol

Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds

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