Synthesis, characterization and cytotoxicity of europium incorporated ZnO–graphene nanocomposites on human MCF7 breast cancer cells

Bera, Susanta; Ghosh, Monisankar; Pal, Moumita; Das, Ν. R.; Saha, Sanjoy Kumar; Dutta, Sourav; Jana, Sunirmal

doi:10.1039/c4ra06243d

Cited by 49 publications

(44 citation statements)

References 62 publications

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“…In addition to this a new absorption band at 1450 cm -1 originating from the skeletal vibration of the graphene sheets[17]. The absorption bands in the range of 420-560 cm -1 can be assigned to the vibrations of Zn-O[18]. The above results strongly confirm the existence of ZnO and graphene components in the composites.…”

supporting

confidence: 63%

Efficient photocatalytic degradation of methylene blue by heterostructured ZnO–RGO/RuO2 nanocomposite under the simulated sunlight irradiation

Reddy

Kim

2015

Ceramics International

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supporting

confidence: 63%

Efficient photocatalytic degradation of methylene blue by heterostructured ZnO–RGO/RuO2 nanocomposite under the simulated sunlight irradiation

Reddy

Kim

2015

Ceramics International

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“…The presence of chemical interactions between the oxygen functionalities of rGO with inorganic moieties such as Zn, Ag and Nd were verified by reduction of the oxygen-containing groups (elimination of peak at 1734 cm À1 ) in GO compared to the NCs. However, in comparison to FTIR spectrum of GO, the intensity of all the vibrational peaks in the rGO derived Ncs, (ZnO/rGO, Ag-ZnO/rGO and Nd-ZnO/ rGO) were found to decrease to a large extent [43]. Moreover, a sharp vibration appeared at 530 cm À1 of the NCs that attributed to vibration region of Zn-O.…”

Section: Resultsmentioning

confidence: 87%

A novel non-invasive strategy for low-level laser-induced cancer therapy by using new Ag/ZnO and Nd/ZnO functionalized reduced graphene oxide nanocomposites

Jafarirad

Torghabe

Rasta

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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In the present research, an effective drug-free approach was developed to kill MCF7 breast cancer cells using low-level laser therapy (LLLT) combined with reduced graphene oxide (rGO)-based hybrid nanocomposites (NCs). Here, fruit extract of Rosa canina was used for the first time to obtain the rGO/ZnO, Ag-ZnO/rGO and Nd-ZnO/rGO NCs by green synthesis. Physico/photochemical properties of these NCs were evaluated using FTIR, XRD, Raman, XPS, SEM/EDX, UV-Vis, DLS and AFM. The potential of the as-synthesized NCs on ROS generating and antioxidant activity were assessed by DPPH. After optimizing the proper concentration of the NCs their anti-tumoral efficacy were evaluated by DAPI staining and MTT assay tests for laser therapy on MCF7 breast cancer cells. Interestingly, cell death was increased dramatically by increasing irradiation dose from 8-32 J/cm and then decreased by enhancing laser dose. The maximum amount of cell death is 50% which was observed in the presence of ZnO/rGO 20% by irradiation dose of 32 J/cm. Furthermore, in comparison with 810 nm, 630 nm lasers were more effective in LLLT of MCF7 cells. The results show the potential of using rGO-based NCs in LLLT, which may be combined with other therapeutic approaches to assist our fight against cancer.

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“…In the C 1s spectra ( Figure S2(a)), three deconvoluted peaks at 284.8, 286.9, and 288.8 eV, can be found in the composites, assignable to the C atoms in C-C, C-O, and C=O groups in GO. By comparing the deconvoluted peaks, it appears that, after loading iron oxide onto GO, the relative intensity of the peak for C-O bonds has been significantly reduced while with the increasing intensity of that for C-C bonds, suggesting the partial conversion of GO to chemically converted graphene (CCG) [51]. Such a conversion may result from the partial reduction of GO by Fe 2+ in the composites.…”

Section: Scheme 1 Schematic Synthesis Of Feo X -Go Nanocompositesmentioning

confidence: 99%

High-performance iron oxide–graphene oxide nanocomposite adsorbents for arsenic removal

Hmidi

2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

182

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We report the synthesis of a new range of iron oxide-graphene oxide (GO) nanocomposites having different iron oxide content (36-80 wt%) as high-performance adsorbents for arsenic removal. Synthesized by co-precipitation of iron oxide on GO sheets that are prepared by an improved Hummers method, the iron oxide in the nanocomposites is featured primarily in the desirable form of amorphous nanoparticles with an average size of ca. 5 nm. This unique amorphous nanoparticle morphology of the iron oxide beneficially endows the nanocomposites with high surface area (up to 341 m 2 g -1 for FeO x -GO-80 having the iron oxide content of 80 wt%) and predominant mesopore structures, and consequently increased adsorption sites and enhanced arsenic adsorption capacity. FeO x -GO-80 shows high maximum arsenic adsorption capacity (q max ) of 147 and 113 mg g −1 for As(III) and As(V), respectively. These values are the highest among all the iron oxide-GO/reduced GO composite adsorbents reported to date and are also comparable to the best values achieved with various sophisticatedly synthesized iron oxide nanostructures. More strikingly, FeO x -GO-80 is also demonstrated to nearly completely (>99.98%) removes arsenic by reducing the concentration from 118 (for As(III)) or 108 (for As(V)) to < 0.02 µg L −1 , which is far below the limit of 10 µg L −1 recommended by the World Health Organization (WHO) for drinking water. The excellent adsorption performance, along with their low cost and convenient synthesis, makes this range of adsorbents highly promising for commercial applications in drinking water purification and wastewater treatment.

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Synthesis, characterization and cytotoxicity of europium incorporated ZnO–graphene nanocomposites on human MCF7 breast cancer cells

Abstract: Eu incorporated ZnO–graphene nanocomposite in human breast cancer cells (MCF7) under a confocal laser scanning microscope.

Cited by 49 publications

References 62 publications

Efficient photocatalytic degradation of methylene blue by heterostructured ZnO–RGO/RuO2 nanocomposite under the simulated sunlight irradiation

Efficient photocatalytic degradation of methylene blue by heterostructured ZnO–RGO/RuO2 nanocomposite under the simulated sunlight irradiation

A novel non-invasive strategy for low-level laser-induced cancer therapy by using new Ag/ZnO and Nd/ZnO functionalized reduced graphene oxide nanocomposites

High-performance iron oxide–graphene oxide nanocomposite adsorbents for arsenic removal

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