Synthesis, characterization and cytotoxicity evaluation of new cerium(III), lanthanum(III) and neodymium(III) complexes

Kostova, Irena; Momekov, Georgi

doi:10.1002/aoc.1205

Cited by 16 publications

(3 citation statements)

References 30 publications

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“…Given that the ligands used are well-known biologically active compounds, we compared them with the lanthanide(III) complexes which we have characterized. [22][23][24][25][26]28,29 Detailed analysis of AOA and Ln(III)-AOA systems revealed that the binding mode in the complexes was bidentate through the carboxylic oxygen atoms. It has been suggested that CCA binds to Ln(III) ions through both oxygen atoms of the carboxylic and carbonylic groups.…”

Section: Resultsmentioning

confidence: 99%

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Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands

et al. 2016

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Section: Resultsmentioning

confidence: 99%

“…The synthesis of the lanthanide(III) complexes of AOA and CCA as well as their theoretical, analytical, spectral, and structural characterization have been previously reported by us. [22][23][24][25][26]28,29 Shortly: the compounds used for preparing the solutions were Merck products, p.a. grade:…”

Section: Complexesmentioning

confidence: 99%

Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands

et al. 2016

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“…Coumarins are an important group of organic compounds that show a wide variety of biological activity as antitumour and antiproliferative effects. [7][8][9][10] Complexes of rare earth metal as cerium(III), lanthanum(III) and neodymium(III), having coumarines as ligand, were examined on different cell lines. [11] Rogers and coworkers reported the cytotoxic activity of acenocumarol samarium(III) and gadolinium(III) complexes against melanoma B16 and fibrosarcoma L929 cell lines.…”

Section: Introductionmentioning

confidence: 99%

New insights on cytotoxic activity of group 3 and lanthanide compounds: complexes with [N,N,N]-scorpionate ligands

Saturnino

Bortoluzzi

Napoli

et al. 2013

Journal of Pharmacy and Pharmacology

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The group 3 and lanthanide (N,N,N)-heteroscorpionate triflate-complexes (M(OTf)2(cybpamd)(THF)) on murine macrophage (J774.A1) cell line, except that of scandium, show a reasonable activity. On human epithelial cervix adenocarcinoma (HeLa) complexes 3, 5 and 6 are significantly more active than cis-platinum, as well as complex 5 is more active on human embryonic kidney (HEK-293) cell line. All the tested complexes are poorly active on human epithelial lung adenocarcinoma (A549) and human melanoma (A375). The different behaviour of the complexes examined (2-8) let us hypothesize that the cytotoxic activity is related to the molecule as a whole and not only to the ligand or the metal ion separately.

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Cytotoxic Activity of Gd(III)‐ and Dy(III)‐Complexes

Kostova¹,

Kiefer

Momekov

2007

Archiv der Pharmazie

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The complexes of gadolinium(III) and dysprosium(III) were synthesized by reaction of the respective inorganic salts with 3,5-pyrazoledicarboxylic acid in amounts equal to metal to ligand molar ratio of 1 : 2. The structures of the final complexes were determined by means of spectral and elemental analyses. To help further the binding mode elucidation in the new Gd(III)- and Dy(III)-complexes of H(3)pdc, detailed vibrational analysis was performed on the basis of comparison of experimental vibrational spectra of the ligand and its Ln(III)-complexes using data theoretically predicted by us earlier, as well as data from the literature about related compounds. Significant differences in the IR and Raman spectra of the complexes were observed as compared to the spectra of the ligand. The ligand and the complexes were tested for their cytotoxic activities on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein and the non-Hodgkin lymphoma-derived DOHH-2, characterized by a re-expression of the anti-apoptotic protein bcl-2 cell lines. The results obtained indicate that the tested compounds exerted a considerable cytotoxic activity upon the evaluated cell lines in a concentration-dependent manner, which enabled the construction of dose-response curves and the calculation of the corresponding IC(50) values. The inorganic salts exerted a very weak cytotoxic effect on these cells. This is in contrast to the lanthanide complexes, which exhibited potent cytotoxic activity, even more than the activity of cisplatin towards K-562 and DOHH-2 cell lines.

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Synthesis, characterization and cytotoxicity evaluation of new cerium(III), lanthanum(III) and neodymium(III) complexes

Abstract: Complexes of cerium(III), lanthanum(III) and neodymium(III

Cited by 16 publications

References 30 publications

Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands

Lanthanide(III) complexes are more active inhibitors of the Fenton reaction than pure ligands

New insights on cytotoxic activity of group 3 and lanthanide compounds: complexes with [N,N,N]-scorpionate ligands

Cytotoxic Activity of Gd(III)‐ and Dy(III)‐Complexes

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