Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes

Ruthenium(II)/4,6-dimethyl-2-mercaptopyrimidine complexes: Synthesis, characterization, X-ray structures and in vitro cytotoxicity activities on cancer cell lines

“…The band attributable to the m(N-H), which appears at 3200-3100 cm À1 in free thiones is absent in the spectra of the complexes, indicating that the SpymMe 2 is coordinated in the deprotonated form [39,40]. Bands from the coordinated ligand , both of very low intensities and a third one, of higher intensity, at 1110 mV, which could correspond to the oxidation of the free NO generated in the electrochemical process [43,44].…”

Ruthenium (II) complexes containing 2-mercaptothiazolinates as ligands and evaluation of their antimicrobial activity

“…Among several transition metals, ruthenium has been highlighted in several publications with a diversity of applications in the biological area [2][3][4][5][6][7]. In this sense, ruthenium-based compounds, including phosphines containing ruthenium complexes, constitute active anticancer [4,[8][9][10][11][12][13], antiprotozoals [14,15], and antiviral [16] agents.…”

Cis-[RuCl(BzCN)(N–N)(P–P)]PF6 complexes: Synthesis and in vitro antitumor activity

“…[RuCl(BzCN)(bipy)(dppe)]PF 6 , were prepared using the methods described in the literature [19]. The syntheses of the complexes cis-[RuCl(BzCN)(bipy)(dppb)]PF 6 , cis-[RuCl(BzCN)(bipy)(dppf)]PF 6 and cis-[RuCl(BzCN)(phen)(dppb)]PF 6 were published elsewhere [20,21].…”

“…Few studies have been performed on the anticancer activity of ruthenium (II) polypyridyl complexes [6][7][8][9][10][11][12]. Therefore, the potential use of ruthenium complexes for cancer treatment has motivated our research group to synthesize new ruthenium complexes of this class and to test them against a range of tumor cells, yielding promising results [13][14][15][16][17][18][19]. In this paper, we describe the results of biological studies of the complexes cis-[RuCl(BzCN)(bipy)(dppe)]PF 6 (1), cis-[RuCl(BzCN)(bipy)(dppb)]PF 6 (2), cis-[RuCl(BzCN)(bipy)(dppf)] PF 6 (3) and cis-[RuCl(BzCN)(phen)(dppb)]PF 6 (4) [ BzCN = benzonitrile; bipy = 2,2`-bipyridine; phen = 1,10-phenanthroline; dppe = 1,2-bis(diphenylphosphino)ethane dppb = 1,4-bis-(diphenylphosphino) butane; dppf = 1,1`-bis(diphenylphosphino)ferrocene].…”