Ruthenium(II)/4,6-dimethyl-2-mercaptopyrimidine complexes: Synthesis, characterization, X-ray structures and in vitro cytotoxicity activities on cancer cell lines

Ruthenium (II) complexes containing 2-mercaptothiazolinates as ligands and evaluation of their antimicrobial activity

“…Among several transition metals, ruthenium has been highlighted in several publications with a diversity of applications in the biological area [2][3][4][5][6][7]. In this sense, ruthenium-based compounds, including phosphines containing ruthenium complexes, constitute active anticancer [4,[8][9][10][11][12][13], antiprotozoals [14,15], and antiviral [16] agents.…”

“…Among the thioamides, the N-heterocyclic thiones can be highlighted as ligands in coordination chemistry due to their potential as metallodrugs [22,23]. As a consequence, several pyridine-2-thiones [24], pyrimidine-2-thiones [3,12,[25][26][27] or thiouracils [28][29][30][31][32] containing transition metal complexes have been isolated and their biological activity assayed.…”

Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB

“…The electrochemical behavior of complex 1-4, in cyclic voltammetric experiments, was similar to that found for other ruthenium compounds reported in the literature, such as the [Ru(SpymMe2-N,S) 2 (dppb)], where a quasi-reversible one-electron Ru II /Ru III redox process was observed, with E 1/2 = 432 mV (Epa = 495 mV and Epc = 369 mV). 31 Complex 2 shows an oxidation process at 787 mV in its cyclic voltammogram, which belongs to the oxidation of the coordinated 2-mercapto-1-methyl-imidazole ligand, in comparison with the process at 813 mV in the free ligand (see Figure S2, SI section).…”

“…The C-S bond distances in the complexes (from 1.720 to 1.753 Å) are longer than expected for a double bond (C=S: 1.62 Å) and shorter than a single bond (C-S: 1.81 Å), suggesting a partial double bond character, where the sulfur atom is negatively charged. 31,32 Cytotoxicity assays and partition coefficient (log P)…”

“…Conductivity values were obtained at room temperature, using 10 -3 M solutions of the complexes in CH 2 Cl 2 , by a Meter Lab CDM2300 instrument. 1 H, 31 Single crystals of 1-4 were obtained at room temperature from dichloromethane/methanol/ether (1:1:3) solutions and were mounted on glass fibers. An Enraf-Nonius Kappa-CCD diffractometer (for 1 and 2) and a Bruker Kappa APEX II Duo diffractometer (for 3 and 4), both equipped with graphite monochromated Mo Kα radiation (λ = 0.71073 Å), were used for intensity data collection at room temperature.…”