Synthesis, characterization and crystal structure of a novel thiocyanate–ruthenium(II) complex

Brito, R.; Batista, Alzir A.; Ellena, Javier; Castellano, Eduardo E.; Diógenes, Izaura C.N.; Lopes, Luiz Gonzaga de França; Sousa, Jackson R. de; Moreira, Ícaro de Sousa

doi:10.1016/j.inoche.2007.09.024

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…37 By keeping this consideration in mind, it is reasonable to conclude that there is an enhancement of the s contribution when L' = 1,4-dt, NCS -and CN -, although the p-acceptor character of these ligands should not be ruled out. [38][39][40] The p stabilization potential, E p , can be estimated by means of electrochemistry if the average potential for the Ru III/II redox couple given by the aquopentaammine (0.07 V) The donor atom is underlined.…”

Section: Characterization Of the Complexesmentioning

confidence: 99%

On the correlation between electronic intramolecular delocalization and Au-S bonding strength of ruthenium tetraammine SAMs

Pinheiro¹,

Paulo²,

Silva³

et al. 2010

J. Braz. Chem. Soc.

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Complexos do tipo trans-[Ru(L)(NH, and L' = CNpy, 1,4-dithiane (1,4-dt), 4-mercaptopyridine (pyS) and thionicotinamide (tna), were synthesized and characterized. SAMs on gold of the complexes containing sulfur were studied by reductive desorption and SERS spectroscopy. Depending on the nature of L', the withdrawing capability of the CNpy ligand is strong enough to partially oxidize the ruthenium atom and, as a consequence, delocalize the s electronic density from the trans located ligand. The reductive desorption results showed that the stability of the SAMs is directly related to this effect.

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Section: Characterization Of the Complexesmentioning

confidence: 99%

On the correlation between electronic intramolecular delocalization and Au-S bonding strength of ruthenium tetraammine SAMs

Pinheiro¹,

Paulo²,

Silva³

et al. 2010

J. Braz. Chem. Soc.

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“…In order to isolate new Cu III complexes based on bis(thiosemicarbazone) with interesting properties, we thought to use the thiocyanate ion (coordinating and anionic ligand) as a coligand which might have more beneficial biological properties. If this pseudohalide leads to complexes with activities in the electrochemical [25][26][27] or magnetic field [28][29][30], the presence of thiocyanate ions has been detected in human biological fluids, saliva and cerebrospinal and in oral cavities in case of stress [31][32][33][34][35][36]. Its role has also been demonstrated in the biological field as a detoxifier [37].…”

Section: Introductionmentioning

confidence: 99%

First divalent copper complex of a terdentate thiosemicarbazido-pyrazoline derived from 2,4-pentanedione bis(thiosemicarbazone): Synthesis, structural characterisation and antimicrobial in vitro activity assessment

Rhoufal

Guesmi²,

Ketatni³

et al. 2021

Polyhedron

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Reaction of 2,4-pentanedione with thiosemicarbazide in 1:2 ratio produces cyclic pyrazoline thiosemicarbazone (H 2 L 2 with L 2 = C 7 H 12 N 6 S 2 ). The obtained ligand has been characterized by elemental analysis, UV-Visible, FTIR, 1 H and 13 C NMR. The results suggest that the ligand is in pyrazolinic form, and finally the structure has been confirmed by single crystal X-ray diffraction.The [(L 2• )Cu(SCN)] copper complex has been prepared by reaction of H 2 L 2 and thiocyanate salt with copper acetates and has been fully characterized by single crystal X-ray diffraction, Hirshfeld surface analysis, as well as UV-Visible, FTIR, and Raman spectroscopies. TGA analysis and magnetic measurements were also performed. Single-crystal X-ray diffraction reveals that the complex is a neutral monomer with copper in distorted tetrahedral environment. The anionic ligand (L 2• )remained in cyclic form and is coordinated as terdentate ligand (SNS). The title complex results from a double deprotonation coupled with a monoelectronic oxidation of H 2 L 2 and it may be seen as a Cu II -ligand radical type complex. The copper ion is tetra coordinated (CuN 2 S 2 ) by two sulfur and one nitrogen of (L 2• )and by thiocyanate nitrogen atoms. The new [(L 2• )Cu(SCN)] complex crystallizes in the monoclinic system and C 2/c space group. Full-Potential Linearized Augmented Planewave Method (FLAPW) calculations based on the Density-Functional Theory (DFT) principle are performed to shed light on both electronic and magnetic structures as well.[(L 2• )Cu(SCN)] showed a greater activity than its parental ligand H 2 L 2 against two strains of the phytopathogenic fungus Verticillium dahliae while a moderate antibacterial activity was recorded with both against Agrobacterium tumefaciens strains and Pseudomonas syringae pv. syringae.

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Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex

et al. 2009

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The organoruthenium complex [(eta(6)-hmb)Ru(en)(Cl)][PF6] (hmb is hexamethylbenzene, en is ethylenediamine) undergoes facile aquation and then reacts with KSCN in unbuffered solution to give the S-coordinated thiocyanato product [(eta(6)-hmb)Ru(en)(S-SCN)]+ which slowly converts to the thermodynamically favored N-bound complex [(eta(6)-hmb)Ru(en)(N-NCS)]+ (1+). Complex 1 was synthesized and characterized by X-ray crystallography and mass spectrometry. Despite its lack of hydrolysis over 24 h, complex 1 exhibits moderate cytotoxicity (IC(50) 24 microM) towards the human ovarian cancer cell line A2780, comparable with that of the chlorido analogue which is thought to be activated (towards potential target DNA) via a rapid aquation (Wang et. al. in Proc Natl Acad Sci USA 102:18269-18274, 2005). Detailed kinetic studies suggest that complex 1 binds to guanosine 5'-monophosphate (GMP) through direct N7 substitution of the N-bound SCN ligand. In the presence of a high concentration of chloride (104 mM), however, complex 1 may bind partly to GMP via Cl substitution.

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Synthesis, characterization and crystal structure of a novel thiocyanate–ruthenium(II) complex

Cited by 7 publications

References 17 publications

On the correlation between electronic intramolecular delocalization and Au-S bonding strength of ruthenium tetraammine SAMs

On the correlation between electronic intramolecular delocalization and Au-S bonding strength of ruthenium tetraammine SAMs

First divalent copper complex of a terdentate thiosemicarbazido-pyrazoline derived from 2,4-pentanedione bis(thiosemicarbazone): Synthesis, structural characterisation and antimicrobial in vitro activity assessment

Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex

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