Synthesis, characterization and crystal structure of novel mononuclear peroxotungsten(VI) complexes. Insulinomimetic activity of W(VI) and Nb(V) peroxo complexes

Dissolution and drug release profiles of phosphate glasses doped with high valency oxides

“…As well as, it was proved that vanadium has the anti-diabetic properties which was initiated in 1985 by John McNeill [11] and used as inhibitors to various phosphate-metabolizing enzymes through binding to the protein matrix. On the other hand, peroxo-molybdenum complexes have shown an antitumor effect [12]. However, despite the proven therapeutic values of vanadium and molybdenum compounds in biomedicine, there is no clear evidence about the suitability of phosphate glasses as drug delivery carriers.…”

Chromium, molybdenum and tungsten

“…Two new mononuclear peroxo complexes of tungsten of the formula (gu) 2 [WO 2 (O 2 ) 2 ] and (gu)[WO(O 2 ) 2 (quin-2-c)] have been synthesized and characterized by elemental analysis, IR, Raman, UV-visible and 1 H NMR spectroscopies, and X-ray crystallography where appropriate. 2 The in vitro insulin-mimetic effect of the complexes were evaluated by the inhibitory effect on free fatty acid release in isolated fat adipocytes treated with epinephrine. 2 Polyoxometallates (POMs) are inorganic polyanionic molecules that have been shown to exhibit activity against tumors and infectious microorganisms; however, the effects of POMs on carbohydrate biosynthesis have never been investigated until recently when it was found that some types of POMs can inhibit the enzymatic activities of specific sialyl/sulfotransferases.…”

Vanadium, niobium and tantalum

“…123 The lone medicinal application of a non-vanadium group V metal was a study detailing the insulin mimetic activity of Nb(V) peroxo complex. 124…”