Dissolution and drug release profiles of phosphate glasses doped with high valency oxides

El-Meliegy, Emad; Farag, Mohammad M.; Knowles, Jonathan C.

doi:10.1007/s10856-016-5711-8

Cited by 21 publications

(20 citation statements)

References 36 publications

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“…A similar effect of MgO incorporation on the support of CaPrich layer formation was found for phosphate-silicate glasses immersed in SBF [52]. The decrease in solution pH observed for tested samples was significantly lower than the one described for similar glasses with higher sodium content [47] and doped with MgO [4]. Moreover, incorporating MgO resulted in increasing the rate of hydration and the rate of breakdown of the phosphate bonds.…”

Section: Biosolubility In Pbssupporting

confidence: 71%

“…Moreover, an increase of solution pH may also be correlated with the release of Ca 2+ and Mg 2+ ions into the solution and chelation with the released phosphate species [47]. The decrease in solution pH observed for tested samples was significantly lower than the one described for similar glasses with higher sodium content [47] and doped with MgO [4]. Moreover, incorporating MgO resulted in increasing the rate of hydration and the rate of breakdown of the phosphate bonds.…”

Section: Biosolubility In Pbsmentioning

confidence: 83%

“…They increased with the increase in Mg content. As described in [ 47 ], the dissolution process of the phosphate-based glasses in an aqueous solution can be divided into two steps: a hydration process and a breakage process. In the hydration process, a hydrated layer is formed on the glass surface due to Na + and H + ion exchange.…”

Section: Resultsmentioning

confidence: 99%

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DC and AC Conductivity, Biosolubility and Thermal Properties of Mg-Doped Na2O–CaO–P2O5 Glasses

et al. 2021

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Bioactive glasses have recently been extensively used to replace, regenerate, and repair hard tissues in the human body because of their ability to bond with living tissue. In this work, the effects of replacing Na2O with MgO on the electrical, biosolubility, and thermal properties of the target glass 10Na2O–60P2O5–30CaO (in mol%) were investigated. The electrical properties of the glasses were studied with the impedance spectroscopy technique. At 473 K, DC conductivity values decreased from 4.21 × 10−11 to 4.21 × 10−12 S cm−1 after complete substitution of MgO for Na2O. All samples had a similar activation energy of the DC conduction process ~1.27 eV. Conduction mechanisms were found to be due to hop of ions: Na+, Mg2+, and probable H+. FTIR analysis showed that, as the Mg content increased, the Q2 unit (PO2−) shifted towards higher wavenumbers. The proportion of Q3 unit (P2O5) decreased in the glass structure. This confirmed that the replacement of Na+ by Mg2+ was accompanied by concurrent polymerization of the calcium–phosphate glass network. The biosolubility test in the phosphate-buffered saline solution showed that the magnesium addition enhanced the biosolubility properties of Na2O–CaO–P2O5 glasses by increasing their dissolution rate and supporting forming CaP-rich layers on the surface. The glass transition temperature increased, and thermal stability decreased substantially upon substitution of Na2O by MgO.

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Section: Biosolubility In Pbssupporting

confidence: 71%

Section: Biosolubility In Pbsmentioning

confidence: 83%

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DC and AC Conductivity, Biosolubility and Thermal Properties of Mg-Doped Na2O–CaO–P2O5 Glasses

et al. 2021

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“…The strong attachment is due to hydrogen bonding between the amino functional groups of vancomycin and the hydrated P-O-H groups in the glass network. 17 A prepared nanogel from dextran and poly(lactide) by in situ cross-linking with a homobifunctional cross-linker through a conventional radical polymerization technique is another compound to increase NP efficiency. Degradation experiments using hen egg lysozyme (Ly) confirmed the biodegradability of the nanogel.…”

Section: Polymer Nanocomposite (Pnc)mentioning

confidence: 99%

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

442

216

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This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

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“…Recently, phosphate glasses have been used as suitable carriers for delivery therapeutic ions such as silver and copper. Amorphous materials have been used for tissue engineering application including metal transition ions such as: Fe 3+ , Cu + , Cu 2+ , Zn 2+ and Ti 2+ in order to improve cell attachment and activate the synthesis of enzymes [14].…”

Section: Introductionmentioning

confidence: 99%

Standard Formation Enthalpy of Na2O–ZnO–P2O5 Series Glasses

2018

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100 − x)NaPO 3 -xZnO (0 ≤ x ≤ 33 mol%) phosphate glasses have been prepared using the conventional melt quenching technique. Amorphous state was checked up by X-ray diffraction. Glasses have been investigated in detail by mean of differential scanning calorimetry, inductively coupled plasma. Incorporation of ZnO oxide increases the T g value and the thermal stability of samples. For this glass series, 31 P solid state magic angle spinning nuclear magnetic resonance (MAS-NMR) spectroscopy revealed the decrease of Q 2 tetrahedral sites and the increase of phosphate dimers (Q 1 ), when ZnO oxide is progressively introduced, suggesting the shortening of metaphosphate chains. Dissolution of glasses has been followed calorimetrically and showed a change in thermal signs resulting from the depolymerization of metaphosphate groups when ZnO oxide is added. A thermochemical cycle involving a number of dissolution and mixing processes have been carried out in order to get the standard enthalpy of formation of these glasses. Calculation of these quantities needs the standard enthalpy of formation of sodium trimetaphosphate. Formation enthalpy of glasses increases with the incorporation of ZnO oxide.

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Dissolution and drug release profiles of phosphate glasses doped with high valency oxides

Cited by 21 publications

References 36 publications

DC and AC Conductivity, Biosolubility and Thermal Properties of Mg-Doped Na2O–CaO–P2O5 Glasses

DC and AC Conductivity, Biosolubility and Thermal Properties of Mg-Doped Na2O–CaO–P2O5 Glasses

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Standard Formation Enthalpy of Na2O–ZnO–P2O5 Series Glasses

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