Synthesis, characterization and biological safety of O-carboxymethyl chitosan used to treat Sarcoma 180 tumor

Zheng, Meiling; Han, Baoqin; Yang, Yan; Liu, Wanshun

doi:10.1016/j.carbpol.2011.04.038

Cited by 111 publications

(46 citation statements)

References 37 publications

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“…The FTIR spectrum of CMC from the synthesis results The functional groups formed on chitosan and CMC can be seen in Table 1. The FTIR spectrum of CMC from the synthesis results obtained in this study showed similar results with the FTIR spectrum of CMC according to Zheng et al [7].…”

Section: Characterization Of Chitosan Cmc and Cmc-benzaldehyde Usinsupporting

confidence: 77%

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Application of Carboxymethyl Chitosan-Benzaldehyde as Anticorrosion Agent on Steel

Darmokoesoemo

Suyanto

Anggara

et al. 2018

International Journal of Chemical Engineering

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Corrosion is one of the problems that is often found in daily life especially in petroleum and gas industry. Carboxymethyl chitosan-(CMC-) benzaldehyde was synthesized as corrosion inhibitor for steel. Corrosion rate was determined by potentiostatic polarization method in HCl 1 M. Dripping and coating, two different treatment, were used to drop and coat steel by CMC-benzaldehyde. The results showed that CMC-benzaldehyde could inhibit the corrosion rate of steel with concentration of 1 g, 3 g, 5 g, and 7 g in 60 mL of solvent. Coating steel with CMC-benzaldehyde with concentration of 7 g/60 mL of solvent and starch of 0.1 g/mL showed the highest efficiency to inhibit corrosion rate of steel. These treatments give corrosion efficiency of 99.8%.

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Section: Characterization Of Chitosan Cmc and Cmc-benzaldehyde Usinsupporting

confidence: 77%

“…In the formation of CMC-benzaldehyde, CMC need to be synthesized by reacting chitosan with NaOH and chloroacetic acid as shown in Figure 3 [7]. CMC formed can dissolve completely in water.…”

Section: Synthesis Of Cmc-benzaldehyde the Synthesis Of Cmcbenzaldehmentioning

confidence: 99%

Application of Carboxymethyl Chitosan-Benzaldehyde as Anticorrosion Agent on Steel

Darmokoesoemo

Suyanto

Anggara

et al. 2018

International Journal of Chemical Engineering

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“…Moreover, CMC increased TGF-α secretion of L02 cells at a concentration of 300 mg/kg (Zheng et al, 2011). Administered intraperitoneally in rats, CMC (1350 mg/kg) had no significant toxicity on the blood system after being absorbed from the abdominal cavity (Yang et al, 2012).…”

Section: Cmc and Cmtmc Toxicitymentioning

confidence: 94%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

440

201

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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“…Fig.2 presented the 1 H NMR spectra of chitosan and HP-chitosan. The proton assignment of chitosan was as follows: 1.91 ppm (CH 3 , acetamido group), 3.04 ppm (CH, C-2 of glucosamine ring), 3.61 ppm (CH, C-2 of glucosamine ring with the substituted amino group), 3.7-3.9 ppm (CH, C-3, 4, 5 and 6 of glucosamine ring), 4.75 ppm (CH, C-1 of glucosamine ring) (Zheng et al, 2011). The characteristic proton assignment of HP-chitosan appeared at 0.99-1.02 ppm (CH 3 , C-9), indicating the hydroxypropylation of chitosan (Xie et al, 2002b;Peng et al, 2005).…”

Section: Characterization Of Hp-chitosanmentioning

confidence: 99%

“…To verify the chemical structure and calculate substitution degree (DS) of HP-chitosan, 1 H NMR spectra of chitosan and HP-chitosan were recorded on a Bruker DPX300 spectrometer (Germany), using acetone as internal standard and 1% DCl D 2 O and D 2 O as solvent, respectively, at 25℃ (Zheng et al, 2011).…”

Section: H Nmr Spectrummentioning

confidence: 99%

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Shao

Han

Dong

et al. 2015

J. Ocean Univ. China

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Hydroxypropyl chitosan (HP-chitosan) has been shown to have promising applications in a wide range of areas due to its biocompatibility, biodegradability and various biological activities, especially in the biomedical and pharmaceutical fields. However, it is not yet known about its pharmacokinetics and biodegradation performance, which are crucial for its clinical applications. In order to lay a foundation for its further applications and exploitations, here we carried out fluorescence intensity and GPC analyses to determine the pharmacokinetics mode of fluorescein isothiocyanate-labeled HP-chitosan (FITC-HP-chitosan) and its biodegradability. The results showed that after intraperitoneal administration at a dose of 10 mg per rat, FITC-HP-chitosan could be absorbed rapidly and distributed to liver, kidney and spleen through blood. It was indicated that FITC-HP-chitosan could be utilized effectively, and 88.47% of the FITC-HP-chitosan could be excreted by urine within 11 days with a molecular weight less than 10 kDa. Moreover, our data indicated that there was an obvious degradation process occurred in liver (< 10 kDa at 24 h). In summary, HP-chitosan has excellent bioavailability and biodegradability, suggesting the potential applications of hydroxypropyl-modified chitosan as materials in drug delivery, tissue engineering and biomedical area.

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Synthesis, characterization and biological safety of O-carboxymethyl chitosan used to treat Sarcoma 180 tumor

Cited by 111 publications

References 37 publications

Application of Carboxymethyl Chitosan-Benzaldehyde as Anticorrosion Agent on Steel

Application of Carboxymethyl Chitosan-Benzaldehyde as Anticorrosion Agent on Steel

Chitosan as a starting material for wound healing applications

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

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