Synthesis, characterization and biological response of magnesium-substituted nanobioactive glass particles for biomedical applications

Prabhu, M. Ramesh; Kandiah, Kavitha; Manivasakan, Palanisamy; Rajendran, V.; Kulandaivelu, P.

doi:10.1016/j.ceramint.2012.08.011

Cited by 41 publications

(26 citation statements)

References 46 publications

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“…3a) confirms the amorphous nature of the prepared NBG particles. 35 The specific surface area of the particles measured from nitrogen adsorption/desorption analysis (Fig. 3b) is 147 m 2 /g.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Deposition of 58SiO₂‐33CaO‐9P₂O₅ Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Saravanakumar

Prabhu

Rajendran

et al. 2013

Int J Applied Ceramic Tech

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The nanobioactive glass (58SiO2‐33CaO‐9P2O5) powders were synthesized by simple sol–gel method. The prepared samples reveal amorphous nature, agglomerated spherical morphology with particle size of 100–150 nm. The specific surface area of nanobioactive glass (NBG) particle is 147 m2/g. The NBG samples were coated on titanium (Ti‐6Al‐4V) alloy through electrochemical deposition method. The particle size of the NBG‐coated surface was in the order of 200–300 nm, and it was confirmed by atomic force microscopy (AFM) analysis. In vitro and AFM studies reveal the existence of higher bioactivity and uniform coating of NBG on implants at 80 V for 1 h.

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Section: Resultsmentioning

confidence: 99%

Electrochemical Deposition of 58SiO₂‐33CaO‐9P₂O₅ Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Saravanakumar

Prabhu

Rajendran

et al. 2013

Int J Applied Ceramic Tech

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“…in vitro studies of NBG particles with alternative compositions (beyond the common SiO 2 ‐CaO or SiO 2 ‐CaO‐P 2 O 5 systems) are limited. In a recent study, Prabhu et al . have investigated the effect of MgO‐substituted NBG particles on in vitro bioactivity using simulated body fluid (SBF) and human gastric adenocarcinoma (AGS) cell line.…”

Section: Applications Of Nanoscale Bioactive Glassesmentioning

confidence: 99%

Nanoscale Bioactive Glasses in Medical Applications

Taygun

Zheng

Boccaccını

2013

Int J of Appl Glass Sci

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This review focuses on recent advances in the development and use of nanoscale silicate bioactive glasses for medical applications. In the context of materials for bone substitution, dental applications, and bone tissue engineering, nanoscale bioactive glasses have been gaining attention due to their expected superior osteoconductivity when compared with conventional (micrometer-sized) bioactive glass materials. A detailed overview of recent developments in the field of nanoscale bioactive glasses will be given, including a summary of common fabrication methods and diverse application areas which include tissue engineering scaffolds and coatings, drug delivery devices, and dentistry. The nanofeatures characteristic of this type of bioactive glasses and the possibilities to expand their use in biomedical applications (nanomedicine) are highlighted.

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“…Silica based ceramics have been the most widely used materials in medical practice, particularly in orthopedic applications [1][2][3][4]. These inorganic compounds have been selected due to their excellent cytocompatibility and in vivo biological responses.…”

Section: Introductionmentioning

confidence: 99%

“…One of the most serious problems that can be caused by the implant is hemolysis. In previous studies it has been demonstrated that the toxicity and hemolytic activity of silica nanoparticles depends on their size, geometry, porosity, and surface charge, due to the presence of silanol groups (OH-) [3,13]. It has been also reported that the reactivity of the silica surface and its ability to produce reactive oxygen species (ROS) may determine the hemolytic activity of these materials [14,15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hemolytic activity and oxidative stress biomarkers in erythrocytes after exposure to bioactive glass nanoceramics

Tsamesidis¹,

Kazeli²,

Pouroutzidou³

et al. 2019

Preprint

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The nature of the surface is critical in determining the biological activity of silica powders. A novel correlation between toxicity and surface properties of bioactive glass ceramics (BGCs) synthesized via the sol-gel method was attempted in this study. The behavior of BGCs after their attachment to the surface of red blood cells (RBCs) was evaluated and their toxic effects were determined based on hemolysis, membrane injury via anti-phosphotyrosine immunoblot of Band 3, lipid peroxidation, potential to generate reactive oxygen species, and antioxidant enzyme production. In particular, three BGCs were synthesized at three calcination temperatures (T1=835 °C, T2=1000 °C and T3=1100 °C). Their toxicity based on hemolysis was dose dependent, while BGC-T2 had the best hemocompatibility in compare with the other BGCs. No BGCs in dosages lower than 0.125mg/ml could damage erythrocytes. On the other hand, all BGCs promoted the production of reactive oxygen species in certain concentrations, with the BGC-T2 producing the lowest ROS and increasing the glutathione levels in RBCs protecting their damage. The results suggest that various factors such as size, a probable different proportion of surface silanols, a balanced mechanism between calcium and magnesium cellular uptake or the different crystalline nature may have contributed to this finding; however, future research is needed to clarify the underlying mechanisms.

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Synthesis, characterization and biological response of magnesium-substituted nanobioactive glass particles for biomedical applications

Cited by 41 publications

References 46 publications

Electrochemical Deposition of 58SiO₂‐33CaO‐9P₂O₅ Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Electrochemical Deposition of 58SiO₂‐33CaO‐9P₂O₅ Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Nanoscale Bioactive Glasses in Medical Applications

Evaluation of hemolytic activity and oxidative stress biomarkers in erythrocytes after exposure to bioactive glass nanoceramics

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Synthesis, characterization and biological response of magnesium-substituted nanobioactive glass particles for biomedical applications

Cited by 41 publications

References 46 publications

Electrochemical Deposition of 58SiO2‐33CaO‐9P2O5 Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Electrochemical Deposition of 58SiO2‐33CaO‐9P2O5 Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Nanoscale Bioactive Glasses in Medical Applications

Evaluation of hemolytic activity and oxidative stress biomarkers in erythrocytes after exposure to bioactive glass nanoceramics

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Product

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Electrochemical Deposition of 58SiO₂‐33CaO‐9P₂O₅ Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications

Electrochemical Deposition of 58SiO₂‐33CaO‐9P₂O₅ Nanobioactive Glass Particles on Ti‐6Al‐4V Alloy for Biomedical Applications