Synthesis, characterization and biological evaluation of novel antimony(III) iodide complexes with tetramethylthiourea and N-ethylthiourea

Öztürk, I.I.; Yarar, S.; Gürgan, Muazzez; Ceyhan, Deniz; Banti, Christina N.; Hadjikakou, Sotiris K.; Manoli, Maria; Moushi, Eleni E.; Tasiopoulos, Anastasios J.

doi:10.1016/j.ica.2019.03.020

Cited by 10 publications

(2 citation statements)

References 47 publications

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“…These group elements are more stable in trivalence and contain a lone electron pair [2]. Antimony(III) and bismuth(III) complexes with ligands containing sulfur donor atoms have been synthesized previously in the literature [3][4][5]. Both lone electron pair and secondary interactions (M … S or M … X, X: Cl, Br, I) lead to various coordination numbers and molecular geometries [6].…”

Section: Introductionmentioning

confidence: 99%

The Hirshfeld Surface Analysis of Antimony(III) and Bismuth(III) Complexes with Dithiocarbamate Ligands

Öztürk¹,

UÇAR²

2022

jbst

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Section: Introductionmentioning

confidence: 99%

The Hirshfeld Surface Analysis of Antimony(III) and Bismuth(III) Complexes with Dithiocarbamate Ligands

Öztürk¹,

UÇAR²

2022

jbst

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“…Antimony is a semimetal possessing a high affinity for coordination with sulfur and nitrogen donor ligands [9,23] and the antimony compounds are widely used as additives to lubricants and in industrial processes [24,25]. Antimony compounds are mainly used in medicine for the clinical treatment of parasitic infections, but they also show other biological activities [26][27][28][29][30][31]. Stimulated by the good performance of platinum anticancer agents, antimony compounds have been developed to show significant potential in tumor therapy [4].…”

Section: Introductionmentioning

confidence: 99%

Thiosemicarbazones and Derived Antimony Complexes: Synthesis, Structural Analysis, and In Vitro Evaluation against Bacterial, Fungal, and Cancer Cells

et al. 2022

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Two antimony complexes {[Sb(L1)Cl2] C1 and [Sb(L2)Cl2] C2} with the thiosemicarbazone ligands {HL1 = 4-(2,4-dimethylphenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL2 = 4-(2,5-dimethoxyphenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide} were introduced. The structures were elucidated on the basis of a CHNS analysis, spectroscopic techniques (UV-Vis and FT-IR), and DMF solution electrical conductivities. Single crystal X-ray diffraction analysis of complex C1 assigned the complex pseudo-octahedral geometry and triclinic P-1 space group. Only the ligand HL1 and its derived complex C1 displayed antifungal activities against Candida albicans and this activity was enhanced from 10 mm to 21 mm for the respective complex, which is the same activity given by the drug “Amphotericin B”. The ligands HL1 and HL2 gave inhibitions, respectively, of 14 and 10 mm against Staphylococcus aureus and 15 and 10 mm against Escherichia coli; however, complexes C1 and C2 increased these inhibitions to 36 and 32 mm against Staphylococcus aureus and 35 and 31 mm against Escherichia coli exceeding the activities given by the ampicillin standard (i.e., 21 mm against Staphylococcus aureus and 25 mm against Escherichia coli). Against MCF-7 human breast cancer cells, the IC50 values of HL1 (68.9 μM) and HL2 (145.4 μM) were notably enhanced to the values of 34.7 and 37.4 μM for both complexes, respectively. Further, the complexes induced less toxicity in normal BHK cells (HL1 (126.6 μM), HL2 (110.6 μM), C1 (>210.1 μM), and C2 (160.6 μM)). As a comparison, doxorubicin gave an IC50 value of 9.66 μM against MCF-7 cells and 36.42 μM against BHK cells.

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Interactions of antimony with biomolecules and its effects on human health

Lai

Lin

et al. 2022

Ecotoxicology and Environmental Safety

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Synthesis, characterization and biological evaluation of novel antimony(III) iodide complexes with tetramethylthiourea and N-ethylthiourea

Cited by 10 publications

References 47 publications

The Hirshfeld Surface Analysis of Antimony(III) and Bismuth(III) Complexes with Dithiocarbamate Ligands

The Hirshfeld Surface Analysis of Antimony(III) and Bismuth(III) Complexes with Dithiocarbamate Ligands

Thiosemicarbazones and Derived Antimony Complexes: Synthesis, Structural Analysis, and In Vitro Evaluation against Bacterial, Fungal, and Cancer Cells

Interactions of antimony with biomolecules and its effects on human health

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