Interactions of antimony with biomolecules and its effects on human health

Lai, Ziyang; He, Mengchang; Lin, Chunye; Ouyang, Wei; Liu, Xitao

doi:10.1016/j.ecoenv.2022.113317

Cited by 40 publications

(20 citation statements)

References 118 publications

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“…The pollution of this metalloid is rapidly emerging worldwide due to its extensive use, especially in China, which is the leading producer of Sb [ 3 ]. Apart from the environmental risk, Sb is considered hazardous to human health, as it is a suspected carcinogen due to its toxicity [ 4 ]. Specifically, trivalent compounds of antimony have been found to be more toxic (10 times) than the pentavalent ones [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Capacity of Nerium oleander to Phytoremediate Sb-Contaminated Soils Assisted by Organic Acids and Oxygen Nanobubbles

Σερίδου

Monogyiou

Syranidou

et al. 2022

Plants

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Antimony (Sb) is considered to be a toxic metalloid of increasing prevalence in the environment. Although several phytoremediation studies have been conducted, research regarding the mechanisms of Sb accumulation and translocation within plants remains limited. In this study, soil from a shooting range was collected and spiked with an initial Sb(III) concentration of 50 mg/kg. A pot experiment was conducted to investigate whether Nerium oleander could accumulate Sb in the root and further translocate it to the aboveground tissue. Biostimulation of the soil was performed by the addition of organic acids (OAs), consisting of citric, ascorbic, and oxalic acid at low (7 mmol/kg) or high (70 mmol/kg) concentrations. The impact of irrigation with water supplemented with oxygen nanobubbles (O2NBs) was also investigated. The results demonstrate that there was a loss in plant growth in all treatments and the presence of OAs and O2NBs assisted the plant to maintain the water content at the level close to the control. The plant was not affected with regards to chlorophyll content in all treatments, while the antioxidant enzyme activity of guaiacol peroxidase (GPOD) in the roots was found to be significantly higher in the presence of Sb. Results revealed that Sb accumulation was greater in the treatment with the highest OAs concentration, with a bioconcentration factor greater than 1.0. The translocation of Sb for every treatment was very low, confirming that N. oleander plant cannot transfer Sb from the root to the shoots. A higher amount of Sb was accumulated in the plants that were irrigated with the O2NBs, although the translocation of Sb was not increased. The present study provides evidence for the phytoremediation capacity of N. oleander to bioaccumulate Sb when assisted by biostimulation with OAs.

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Section: Introductionmentioning

confidence: 99%

Capacity of Nerium oleander to Phytoremediate Sb-Contaminated Soils Assisted by Organic Acids and Oxygen Nanobubbles

Σερίδου

Monogyiou

Syranidou

et al. 2022

Plants

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“…It is known that metal ions other than Mg 2+ , including Tb 3+ , can displace Mg 2+ from its high-affinity binding sites ( Hargittai and Musier-Forsyth, 2000 ). While Sb can bind to and interact with nucleic acids ( Lai et al., 2022 ), it is not clear whether trivalent antimony could displace Mg 2+ . Our hypothesis is that ribosome-RNA complexes serve as ‘off-target traps’ in which Sb binds to RNA.…”

Section: Discussionmentioning

confidence: 99%

Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach

Ibarra-Meneses

Corbeil²,

Wagner³

et al. 2022

Front. Cell. Infect. Microbiol.

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Visceral leishmaniasis (VL), caused by Leishmania infantum, is an oft-fatal neglected tropical disease. In the absence of an effective vaccine, the control of leishmaniasis relies exclusively on chemotherapy. Due to the lack of established molecular/genetic markers denoting parasite resistance, clinical treatment failure is often used as an indicator. Antimony-based drugs have been the standard antileishmanial treatment for more than seven decades, leading to major drug resistance in certain regions. Likewise, drug resistance to miltefosine and amphotericin B continues to spread at alarming rates. In consequence, innovative approaches are needed to accelerate the identification of antimicrobial drug targets and resistance mechanisms. To this end, we have implemented a novel approach based on thermal proteome profiling (TPP) to further characterize the mode of action of antileishmanials antimony, miltefosine and amphotericin B, as well as to better understand the mechanisms of drug resistance deployed by Leishmania. Proteins become more resistant to heat-induced denaturation when complexed with a ligand. In this way, we used multiplexed quantitative mass spectrometry-based proteomics to monitor the melting profile of thousands of expressed soluble proteins in WT, antimony-resistant, miltefosine-resistant, and amphotericin B-resistant L. infantum parasites, in the presence (or absence) of the above-mentioned drugs. Bioinformatics analyses were performed, including data normalization, melting profile fitting, and identification of proteins that underwent changes (fold change > 4) caused by complexation with a drug. With this unique approach, we were able to narrow down the regions of the L. infantum proteome that interact with antimony, miltefosine, and amphotericin B; validating previously-identified and unveiling novel drug targets. Moreover, analyses revealed candidate proteins potentially involved in drug resistance. Interestingly, we detected thermal proximity coaggregation for several proteins belonging to the same metabolic pathway (i.e., tryparedoxin peroxidase and aspartate aminotransferase in proteins exposed to antimony), highlighting the importance of these pathways. Collectively, our results could serve as a jumping-off point for the future development of innovative diagnostic tools for the detection and evaluation of antimicrobial-resistant Leishmania populations, as well as open the door for new on-target therapies.

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“…Antimony (Sb) is a non-essential metalloid whose concentration in the environment is rapidly increasing due to anthropogenic activity such as mining, smelting, waste incineration, and excessive use of commercial fertilizers [ 1 , 2 ]. This metalloid is also listed as a potential carcinogen [ 3 ] and several studies have already recorded its detrimental effects on human health [ 4 , 5 , 6 ]. Plants can take up Sb from the soil and accumulate it in their tissues, which can be linked with many negative impacts on plant growth and development.…”

Section: Introductionmentioning

confidence: 99%

“…Accumulation of Sb in the plants can be a problem due to its entry into the food chain. It is well-documented that Sb has a negative effect on human health and causes diseases [ 6 ]. High amount of Sb in the human body increases immunological, neurological, reproductive, and developmental problems as well as the cancer of multiple organs [ 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is well-documented that Sb has a negative effect on human health and causes diseases [ 6 ]. High amount of Sb in the human body increases immunological, neurological, reproductive, and developmental problems as well as the cancer of multiple organs [ 6 , 12 ]. Therefore, in order to minimize this threat, it is essential to find a solution of how to reduce the Sb concentration in plants and increase their defense mechanisms against this stress.…”

Section: Introductionmentioning

confidence: 99%

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Silicon Actuates Poplar Calli Tolerance after Longer Exposure to Antimony

Labancová

Vivodová

Šípošová

et al. 2023

Plants

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The presence of antimony (Sb) in high concentrations in the environment is recognized as an emerging problem worldwide. The toxicity of Sb in plant tissues is known; however, new methods of plant tolerance improvement must be addressed. Here, poplar callus (Populus alba L. var. pyramidallis) exposed to Sb(III) in 0.2 mM concentration and/or to silicon (Si) in 5 mM concentration was cultivated in vitro to determine the impact of Sb/Si interaction in the tissue. The Sb and Si uptake, growth, the activity of superoxide dismutase (SOD), catalase (CAT), guaiacol-peroxidase (G-POX), nutrient concentrations, and the concentrations of photosynthetic pigments were investigated. To elucidate the action of Si during the Sb-induced stress, the impact of short and long cultivations was determined. Silicon decreased the accumulation of Sb in the calli, regardless of the length of the cultivation (by approx. 34%). Antimony lowered the callus biomass (by approx. 37%) and decreased the concentrations of photosynthetic pigments (up to 78.5%) and nutrients in the tissue (up to 21.7%). Silicon supported the plant tolerance to Sb via the modification of antioxidant enzyme activity, which resulted in higher biomass production (increased by approx. 35%) and a higher uptake of nutrients from the media (increased by approx. 10%). Silicon aided the development of Sb-tolerance over the longer cultivation period. These results are key in understanding the action of Si-developed tolerance against metalloids.

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Interactions of antimony with biomolecules and its effects on human health

Cited by 40 publications

References 118 publications

Capacity of Nerium oleander to Phytoremediate Sb-Contaminated Soils Assisted by Organic Acids and Oxygen Nanobubbles

Capacity of Nerium oleander to Phytoremediate Sb-Contaminated Soils Assisted by Organic Acids and Oxygen Nanobubbles

Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach

Silicon Actuates Poplar Calli Tolerance after Longer Exposure to Antimony

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