Synthesis, characterization and biological evaluation of novel benzimidazole derivatives

Akhter, Zareen; Asghar, Muhammad Adeel; Mirza, Bushra; Ismail, Hammad; Liaqat, Faroha; Kalsoom, Saima; Ashraf, Ahmad Raza; Muhammad, Shabbir; Qayyum, Muhammad Abdul; McKee, Vickie

doi:10.1080/07391102.2019.1617783

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…The intermediate product 1g – 1o was obtained after purification by recrystallization from anhydrous ethanol (Scheme ). The substrates 2a – 2f were synthesized based on the reported literature. − …”

Section: Methodsmentioning

confidence: 99%

Design, Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Chiral Isoxazoline-Benzofuran-Sulfonamide Derivatives

Yan,

Bao,

Wang

et al. 2024

J. Agric. Food Chem.

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Succinate dehydrogenase (SDH) is one of the most important molecular targets for the development of novel fungicides. With the emerging problem of resistance in plant fungal pathogens, novel compounds with high fungicidal activity need to be developed, but the study of chiral pesticides for the inhibition of highly destructive plant pathogens has been rarely reported in recent years. Therefore, a series of novel chiral isoxazoline-benzofuran-sulfonamide derivatives were designed to investigate potential novel antifungal molecules. The chiral target compound 3a was cultured as a single crystal and confirmed using X-ray diffraction. All the target compounds were tested for antifungal activity, and compounds 3c, 3i, 3s, and 3r were found to have significant antifungal effects against S. sclerotiorum with EC 50 values of 0.42 mg/L, 0.33 mg/L, 0.37 mg/L, and 0.40 mg/L, respectively, which were superior to the commercial fungicide fluopyram (EC 50 = 0.47 mg/L). The IC 50 value of compound 3i against the SDH of S. sclerotiorum was 0.63 mg/mL, which was further demonstrated by enzyme activity assays. Scanning electron microscopy showed that 3i had a significant inhibitory effect on S. sclerotiorum. In addition, the fluorescence quenching analysis assay indicated that compound 3i had a similar effect with the positive control fluopyram. Molecular docking exhibited that target compounds with chiral configuration had better affinity than racemic configuration, and 3i possessed stronger action than fluopyram, which was in keeping with the in vitro test results. These results would provide a basis and reference for the development of novel chiral fungicides.

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Section: Methodsmentioning

confidence: 99%

Design, Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Chiral Isoxazoline-Benzofuran-Sulfonamide Derivatives

Yan,

Bao,

Wang

et al. 2024

J. Agric. Food Chem.

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“…Eggs of brine shrimp ( Artemia salina ) (Ocean Star Inc., USA) were hatched within a square box by developing a synthetic seawater environment by blending commercial salt in double distilled water. After 24 h, brine shrimp larvae (Phototropic nauplii) were transferred to glass vial using a Pasteur pipette ( Mahmood et al, 2019 ). 25 µL solutions (200, 66.6, 22.2 and 7.4 µg/mL) of Ca-AgNPs and PEGMA capped NPs were added to each vial.…”

Section: Methodsmentioning

confidence: 99%

“…After 24 h the no of viable shrimps were counted using a 3X magnifying glass. Finney (1971) software was used to determine the lethal dose that killed 50% shrimps (LD50) ( Mahmood et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Hybridization of green synthesized silver nanoparticles with poly(ethylene glycol) methacrylate and their biomedical applications

Anwar

Khan

Shah

et al. 2022

PeerJ

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In the present research, a rapid, simple and efficient green method is used for the incorporation of silver nanoparticles (AgNPs) into poly(ethylene glycol) methacrylate (PEGMA) to create biocatalysts with excellent properties for pharmaceutical purpose. In the first phase, Caralluma tuberculata capped AgNPs (Ca-AgNPs) were prepared using green synthetic approach and in the second phase Caralluma tuberculata capped AgNPs were hybridized with poly(ethylene glycol) methacrylate to form PEGMA-AgNPs. Both the virgin (naked or uncapped) and polymer-capped materials were characterized spectroscopically and their results were compared. Fourier transform infrared spectroscopy showed no new peak after the capping procedure, showing that only physical interactions takes place during capping. After PEGMA capping, the spectra of the AgNPs red shifted (from 450 nm to 520 nm) and the overall particle size of AgNPs increased. Catalytic activity of the nanoparticles and hybrid system were tested by choosing the catalytic reduction of 4-nitrophenol (4-NP) as a model reaction. Both synthesized NPs and polymer capped NPs exhibits catalytic activity for the reduction of 4-NP to 4-aminophenol. The polymer hybrid exhibits remarkable antiproliferative, antioxidant, cytotoxic, antidiabetic and antileishmanial activities.

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Novel cyanochalcones as potential anticancer agents: apoptosis, cell cycle arrest, DNA binding, and molecular docking studies

Ragheb,

Abdelrashid,

Elzayat

et al. 2024

Journal of Biomolecular Structure and Dynamics

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Synthesis, characterization and biological evaluation of novel benzimidazole derivatives

Cited by 6 publications

References 49 publications

Design, Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Chiral Isoxazoline-Benzofuran-Sulfonamide Derivatives

Design, Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Chiral Isoxazoline-Benzofuran-Sulfonamide Derivatives

Hybridization of green synthesized silver nanoparticles with poly(ethylene glycol) methacrylate and their biomedical applications

Novel cyanochalcones as potential anticancer agents: apoptosis, cell cycle arrest, DNA binding, and molecular docking studies

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