Synthesis, characterization and biological evaluation (antifungal and antibacterial) of new derivatives of indole, benzotriazole and thioacetyl chloride

Ibrahim, Darda' Aziz; Khalaf, Sarab Dalaf; Ahmed, Naglaa Abd Al-Salam; Dalaf, Adil Hussein

doi:10.1016/j.matpr.2021.05.160

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…In 25 ml of tetrahydrofuran (THF), Schiff bases prepared [13] (0.002 mol) are combined with (0.004 mol, 0.26 gm) of sodium azide and microwaved for (5)(6)(7)(8)(9)(10)(11) minutes (ability 600 W). The residue was extracted, and ethanol was used to re-crystallize it [15]. Table (1) describes the physical properties.…”

Section: Prepare Of Tetrazole [A 1 -A 5 ] In the Microwave Methodsmentioning

confidence: 99%

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Dalaf

Jumaa

Aftana

et al. 2022

KEM

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In this study, new tetrazole [A1-A5] were prepared by the reaction of Schiff base with sodium azide in tetrahydrofuran (THF) by the traditional method (reflux) and microwave technology. The prepared compounds were characterized by physical properties, UV-Vis, FT-IR, 1H-NMR, 13C-NMR spectral, and C.H.N analysis. TLC checked the purity of these compounds. Antibacterial behaviors were investigated against a variety of bacteria, including Escherichia coli, and Klebsiella pneumonia Gram (-) ve, Staphylococcus aureus, and Staphylococcus epidermidis Gram (+) ve. The laser efficacy of the [A1-A5] was evaluated after they were radiated by laser for (10, 20, 30) seconds. As the melting point, and color of the substances were determined, it was discovered that they were unaffected, and did not disintegrate or polymerize. Using the Chem3D 19.0 program, the heat of the formulation of the [A1-A5] was investigated.

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Section: Prepare Of Tetrazole [A 1 -A 5 ] In the Microwave Methodsmentioning

confidence: 99%

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Dalaf

Jumaa

Aftana

et al. 2022

KEM

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“…Darda' Aziz Ibrahim et al [37] developed a protocol for synthesis of new derivatives of indole (108)(109)(110). Initially 2amino-5-mercapto-1,3,4-thiadiazole (100) was prepared by thiosemicarbazone (99) in absolute ethanol with anhydrous sodium carbonate and CS 2 followed by reaction with benzaldehyde derivatives in glacial acetic acid and refluxed for 4 h to yield Schiff bases (101-103).…”

Section: Acid Followed By Refluxing For 1 H To Yield Final Compounds ...mentioning

confidence: 99%

Insight into Indole‐Based Heterocyclic Scaffolds: A Medicinal Chemistry Perspective

Bendi,

Versha,

Rajni

et al. 2023

ChemistrySelect

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The importance of indole‐based heterocycle scaffolds in medicinal chemistry has increased as a result of their significant pharmacological and biological characteristics. These compounds′ importance in the discovery and creation of cutting‐edge medications to treat a variety of diseases is an instance of their worth. The current study highlights the numerous methods available to create different indole‐based heterocycle scaffolds and their favourable medical uses with the literature that has been published up to 2023.

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“…Which is summed up by preparing a nutrient medium consisting of nutritional compounds for bacteria. (19) (20) It was prepared and sterilized in an autoclave, and it consists of:…”

Section: Synthesis Of Bacterial Inoculationmentioning

confidence: 99%

Preparing Some Nano Composites Decorated with Some Pharmaceutical Compounds and Evaluating their Biological Effectiveness

Shakir

2023

IJMRA

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The aim of this study was to use electrochemical methods to synthesise and characterise several derivatives of graphene oxide or nanosheets of reduced graphene oxides (A3) and (A4). Melting-point analysis was performed on the produced compounds. SEM, XRD, TEM, and AFM. It's not environmentally friendly, but it's quick and doesn't cost a lot of money. All of the separated chemicals can be stored safely at room temperature. Bacteria have performed biological research on compounds created using the nanotechnology approach. And assess the produced compounds' capacity to limit bacterial growth and their biological efficacy against Gram-positive and Gram-negative bacteria.

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Synthesis, characterization and biological evaluation (antifungal and antibacterial) of new derivatives of indole, benzotriazole and thioacetyl chloride

Cited by 6 publications

References 24 publications

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Insight into Indole‐Based Heterocyclic Scaffolds: A Medicinal Chemistry Perspective

Preparing Some Nano Composites Decorated with Some Pharmaceutical Compounds and Evaluating their Biological Effectiveness

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