Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Abstract

In this study, new tetrazole [A1-A5] were prepared by the reaction of Schiff base with sodium azide in tetrahydrofuran (THF) by the traditional method (reflux) and microwave technology. The prepared compounds were characterized by physical properties, UV-Vis, FT-IR, 1H-NMR, 13C-NMR spectral, and C.H.N analysis. TLC checked the purity of these compounds. Antibacterial behaviors were investigated against a variety of bacteria, including Escherichia coli, and Klebsiella pneumonia Gram (-) ve, Staphylococcus aureus, and Staphylococcus epidermidis Gram (+) ve. The laser efficacy of the [A1-A5] was evaluated after they were radiated by laser for (10, 20, 30) seconds. As the melting point, and color of the substances were determined, it was discovered that they were unaffected, and did not disintegrate or polymerize. Using the Chem3D 19.0 program, the heat of the formulation of the [A1-A5] was investigated.

Determination of cefdinir in pharmaceutical preparations by oxidative conjugation method

“…Effect of oxidizing agent volume: Increasing volume of the oxidizing agent was used with a concentration of 0.001 molar to find out the volume that gives the highest absorption, and the results are shown in Figure (5), as it was found that the best volume of acid added is (1ml) 3) by adopting the same optimal conditions, where the time 10 minutes was sufficient to complete the oxidation process. Calibration curve: The calibration curve for (Cef) with P-aminobenzoicacid showed the linearity at concentrations rang of (5-75) μg/ml, as show in figure (6).…”

“…Effect of base volume: The volume that delivers the maximum absorption was determined by adding increasing volumes of NaOH at a concentration of 1.0 molar, with the optimal volume added from the base being 0.5 m. 0M each of them, as well as the same added volume of 0.5 ml, were used to find out which base gives the best absorption when forming a total, as it was found that the best M base is NaOH, and it is shown in Table (6) Table ( 6 Effect of Time: The effect of product stability was investigated for its significance in determining the period of time during which it remains constant, as well as the interaction that time was followed using optimum conditions every ten minutes for 30 minutes. Effect of oxidation time: The time at which the drug is oxidized using the oxidizing agent NBS was studied, and before completing the rest of the additions and completing the volume in the volumetric vial, and the results are shown in Table (8), depending on the same optimal conditions, where the time 10 minutes was sufficient to complete the oxidation process.…”

“…Cefdinir (Figure 1), is an antibacterial agent that can be taken orally (1), It belongs to BCS Class IV, a semisynthetic broad-spectrum third-generation cephalosporin with low solubility and permeability (2) , for him a consistent white to yellow brown color (3), It is water insoluble and pH affects its solubility (4) , When it enters the body, some enzymes transform it into an active chemical that is poisonous to microscopic and parasitic organisms, preventing them from reproducing by interfering with their DNA (5), is processed insignificantly and eliminated in the urine (6) , Allergic responses to cefdanir have been observed, including rash, itching, fever, and arthralgia (7), headache (8) , cholestatic jaundice(9), It's also used to treat infections of the urinary tract. (10).…”

“…(10): Effect of vol. (ml) of NaOH on the absorption values Effect of the used different bases: The bases of NH4OH, KOH, NaOH with a concentration of 1.0M each of them, as well as the same added volume of 0.5 ml, were used to find out which base gives the best absorption when forming a total, as it was found that the best M base is NaOH, and it is shown in Table(6)…”

Preparation and characterization of new compounds for schiff base derived from furfural, study of some physical applications and evaluation of their biological activity

“…Figures (30 -23) show that the compound [WS.X1] increased the inhibition values against all types of bacteria; This is because the compound is aliphatic, and despite the decrease in the basicity, there was an increase in the inhibition values; This is due to the presence of (CH2) groups of electrons. For compound [WS.X4], the highest braking rate was obtained; This appears to be due to atoms of heterogeneous groups such as (N, S, O) despite the low basicity [28].…”