Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Xipamide Drug

Abstract

The present paper deals with the synthesis and characterization of metal complexes of Schiff base derived from xipamide, a diuretic drug. The bidentate ligand is derived from the inserted condensation of 5-aminosulfonyl-4-chloro-N-2,6-dimethyl phenyl-2-hydroxybenzamide (Xipamide) with salicylaldehyde in a 1 : 1 molar ratio. Using this bidentate ligand, complexes of Hg(II), Zn(II), and VO(IV) with general formula ML2 have been synthesized. The synthesized complexes were characterized by several techniques using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, mass spectra, and particle size analysis. The elemental analysis data suggest the stoichiometry to be 1 : 2 [M : L]. All the complexes are nonelectrolytic in nature as suggested by molar conductance measurements. Infrared spectral data indicate the coordination between the ligand and the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms. Spectral studies suggest tetrahedral geometry for Hg(II), Zn(II) complexes, and square pyramidal geometry for VO(IV) complex. The pure drug, synthesized ligand, and metal complexes were screened for their antifungal activities against Aspergillus niger and Aspergillus flavus. The ligand and its Hg(II) and VO(IV) complexes were screened for their diuretic activity too.

Synthesis, Characterization, Antimicrobial and Anti-Inflammatory Studies of Some Novel Schiff Base Metal Complexes Derived From the Drug, Diclofenac

“…Moreover, the new peaks in the range of 764-743, 671-641, and 476-436 cm -1 in all the metal complexes are due to M-O, M-S and M-N bonding, respectively. [19][20][21][22] Table-2: Selected Infrared Data of the Schiff Base Ligand and its Metal Complexes…”

Synthesis of unsymmetrical, Symmetrical Schiff bases by Ultrasonic Assisted Technique and Biological Evaluation of their Metal-Complex

“…The cross-linking agents can also be derived from metal complexes with O, N or S ligands. For example, an intra coordination salt such as salicylates or anthranilates and aliphatic or aromatic amines can form strong five-or six-membered chelate rings which are able to produce metal containing cross-linking agents with the required properties [10][11][12]. The complexes of Co(II), Ni(II), and Cu(II) ions with the Schiff bases derived from the condensation of salicylaldehyde and o-aminophenol or 2-aminobenzoic acid were synthesized and characterized by different techniques, in particular, elemental analysis and molar conductance measurements as well as IR and electronic spectroscopy [13,14].…”