Synthesis, characterization and biological activity studies of mixed paracetamol- ascorbic acid metal complexes

Abstract

ABSTRACT:Mixed ligand-metal complexes of Paracetamol and Ascorbic acid were synthesized using FeCl2.4H2O, CuCl2.2H2O, NiCl2.6H2O, CoCl2.6H2O and ZnSO4 salts based on two concentrations (3mmol and 5mmol). The complexes were characterized using some physical techniques such as melting point, solubility, conductivity measurement and spectroscopic analyses such as UV-Visible spectroscopy, Atomic absorption spectroscopy, and Infrared spectroscopy. Based on the physical and spectroscopic results, the coordination of the metal was through the phenolic oxygen and carbonyl oxygen in paracetamol while it was through the carbonyl oxygen and C-2 hydroxyl group in ascorbic acid. The complexes were also screened for their antimicrobial activities against some isolates of

Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

“…Electronic spectrum of Ni (II) complex displays bands in 9837, 18092 and 23426 ranges which have been assigned to the transitions, 3 A 2 g→ 3 T 2 g ( f) , 3 A 2 g (f) → 3 T 1 g (f) and 3 A 2 g (f) → 3 T 1 g (p) ,which indicates that the complex is octahedral (15,16) Uv-vis spectrum of Cu(II) complex displays bands in the position 48540 and 43471 cm -1 which have been attributed to the charge transfer. Also, other bands appeared at 15974 cm -1 as abroad band correspond to 2 Eg→ 2 T 2 g transition, the emergence of the broad cupper band is due to the influence of John-Tellar (15,17), Fig 1 . Finally, the electronic spectrum of yellow Zn (II) complexes has one band at 42325cm -1 which can correspond to the C-T and also two bands at 34278 and 21346 cm -1 which attributed to the ( − * ) and ( − * ) transitions (15,9) ,the geometry of this complex can be observed in Fig.…”

“…The significance of nitrogen-containing complexes in their application as high-efficiency biopharmaceuticals to many fungi is significant, for nitrogen possesses a high degree of consistency with metal in a base or neutral medium because it owns a single electronic pair that can be shared with another atom (1) .Schiff bases form a crucial class of the best and extensively used organic compounds and have a wide range of applications in numerous fields comprising analytical and biological fields (2). Schiff bases have distinction in medicinal and pharmaceutical arenas due to their expansive spectrum of biological activity such as antibacterial, antifungal (2,3), anticancer (4) and herbicidal activities (5). Amoxicillin (C 16 H 19 N 3 O 5 S) is a semi synthetic penicillin type antibiotic which has little effect toward gram-negative bacteria and high effect toward gram-positive bacteria (6).…”

A Short Review: Chemistry of Curcumin and Its Metal Complex Derivatives

“…Tukki and Akhtar (2016) [29] 2016 have reported synthesis of (CUM) -Fe(III) Complex as potential photo cytotoxic agents selectivity towards cancer cells. Reiam (2018) [30] Zainab (2018) [32] reported synthesized Schiff base derived from isatin and 2-aminopyridine mixed ligand complexes. (N 3 ‾) -curcumin.…”

Salmonella typhi and Brucella melitensis prevalence Among Blood Donors Prevalence in Diyala Province

“…Research area on this coordination form was not extensively investigated; only few metals complexes were reported. 11,18,19 Mg (II), Ca (II), Ba (II), Sr (II) display complexes with paracetamol in which the metal connected to the ligand through the lone pair of nitrogen and the carbonyl amide unit and these phases found to have 1:2 stoichiometric ratio for the metals and the ligand. 20,21 The biological behaviors of the complexes towards some bacterial species such as Bacillus, Serratia were also intensively examined.…”