Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

Abstract

In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been prepared. The compounds have been characterized by different means such as FT-IR, UV-Vis, magnetic moment, elemental microanalyses (C.H.N), atomic absorption, and molar conductance. It is obvious when looking at the spectral study that the overall complexes obtained as monomeric structure as well as the metals center moieties are two-coordinated with octahedral geometry excepting Co complexes that existed as a tetrahedral geometry. Hyper Chem-8.0.7 program was employed, after calculating the heat of formation (ΔH°f ) , binding energy (ΔE b ), dipole moment( µ ), and FT-IR frequencies are carried out in gas phase, the geometric shape is suggested. The compounds have been also screened for their bioactivity to antibacterial and antifungal.

Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one

“…Meanwhile, new ranges appeared in the 430-578 cm −1 range (Table 2). These bands apply to the formation of M-O and M-N bonds to confirm the development of complexes [20]. All FTIR spectra are shown in Fig.…”

“…When the infrared spectra of the complexes were compared to the spectrum of the ligand, a considerable change was discovered as bands vanished or moved to other frequencies, and new bands were developed that were not present in the L ligand spectrum. The modifications are summarized below: the coordination of the metal ions to the nitrogen azomethine causes a shift-high in the frequency of C=N value [20]. The new bands indicated conversion of the C=O group in ligand from 1712 cm −1 into new bands.…”

“…The ligand's electronic spectra displayed significant absorption at 305, 344, and 437 nm that are related to π→π * , n→π * , and charge transfer (CT), respectively [21]. Changes in the placement of absorption bands in the complex spectra were detected, indicating metal ion coordination via the azomethine and oxygen functional groups [19][20]. The Co(II) complex spectrum showed four bands at 385, 527, 705, and 931 nm, which represented the permitted transitions and had a magnetic moment of 4.79 MB.…”

Molecular Docking, Synthesis and Evaluation for Antioxidant and Antibacterial Activity of New Oxazepane and Benzoxazepine Derivatives

“…The prepared compounds (1B-3C) were examined for antibacterial activity against two types of bacteria (S. aureus, and E. coli) at the concentration of (10 -7 -10 -11 µm inhibition) by diffusion method in Mueller-Hinton agar medium [34][35][36] . After one day, a zone appeared around each disc.…”

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“…The FT-IR spectrum for free ligand showed five major bands 1620 cm -1 , 1581 cm -1 , 1222 cm -1 , 740 cm -1 , and 2893, 2903 cm -1 , returned to ν CH=Nschiff (24), νC=Ncyclic of thiadiazole (24), νCSC (18), ν CS (21), and ν (CH2-N) (25), respectively. Some of these peaks are shifted towards the high or low frequencies when they are coordinated with the metal ions.…”