Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

Microwave Assisted Synthesis of some Novel Sulphonamide Bearing Pyrazolone Core Structure

“…Keeping in view of this and in continuation of our search on biologically potent molecules [20][21][22][23], we hereby report the synthesis and antimicrobial property of some new pyrazolone derivatives Multi drug resistance is widespread with specific relevance to Gram positive and Gram negative bacteria. Infections caused by these organisms create a serious challenge to the community.…”

Synthesis of a Series of Novel Tetra-tert-butylcalix[4]arene Linked to 1,2,4-Triazole and 1,3,4-Oxadiazole Derivatives

“…Calix [4]arenes have been investigated for their biological proprieties; for example hydrophilic derivatives have shown interesting levels of activity against bacteria, cancerous cell, fungi, enveloped virus thrombosis, and fibrosis diseases. [8][9][10][11][12][13][14] 1,2,4-Triazole-5-thiones and 1,3,4-oxadiazole-5-thiones scaffolds are heterocyclic compounds containing five membered rings and their derivatives have been studied due to their diverse pharmacological proprieties, such as antibacterial and antifungal, [15][16][17][18][19][20][21][22] antimicrobial, [23][24][25] anti-inflammatory, 22,26 and antiviral activities. 27,28 Calix [4]arenes represent a third generation of supramolecular hosts after cyclodextrins and crown ethers, with unique three-dimensional structures.…”

Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives

“…A Wide variety of substituted 1,3,4-oxadiazoles have attracted considerable attention in the field of drug discovery because of their wide range of pharmacological activities, including antiproliferative [4], antifungal [5], antibacterial [6,7], anticancer [8], anti-tubercular [9], GABAA receptor agonists [10], anti-inflammatory [11], anti HIV [12]. Different methods have been reported for the synthesis of 1,3,4-oxadiazoles involving cyclization of 1,4-di-substituted thiosemicarbazide in the presence dicyclohexylcarbodiimide (DCC) [13].…”