Synthesis, characterization, and biological activity of selenium nanoparticles conjugated with polysaccharides

Shi, Xiaodan; Tian, Yongtao; Wu, Jiulin; Wang, Shaoyun

doi:10.1080/10408398.2020.1774497

Cited by 81 publications

(54 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chemically synthesized NCs can be packed in the process of synthesis into polymer molecules, in particular, into polysaccharides [ 15 , 16 , 17 , 18 ]. Hybrid nanosystems based on Se NCs can be synthesized by the method of chemical reduction using various stabilizers and reducing agents: bovine serum albumin (BSA) + ascorbic acid, chitosan + ascorbic acid, and glucose.…”

Section: Discussionmentioning

confidence: 99%

Selenium Nanocomposites in Natural Matrices as Potato Recovery Agent

Perfileva

Ножкина

Ганенко

et al. 2021

IJMS

View full text Add to dashboard Cite

The paper presents a study of the effect of chemically synthesized selenium nanocomposites (Se NCs) in natural polymer matrices arabinogalactan (AG) and starch (ST) on the viability of the potato ring rot pathogen Clavibacter sepedonicus (Cms), potato plants in vitro, and the soil bacterium Rhodococcus erythropolis. It was found that the studied Se NCs have an antibacterial effect against the phytopathogenic Cms, reducing its growth rate and ability to form biofilms. It was revealed that Se NC based on AG (Se/AG NC) stimulated the growth and development of potato plants in vitro as well as their root formation. At the same time, Se did not accumulate in potato tissues after the treatment of plants with Se NCs. The safety of the Se NCs was also confirmed by the absence of a negative effect on the growth and biofilm formation of the soil bacterium R. erythropolis. The obtained results indicate that Se NCs are promising environmentally safe agents for the protection and recovery of cultivated plants from phytopathogenic bacteria.

show abstract

Section: Discussionmentioning

confidence: 99%

Selenium Nanocomposites in Natural Matrices as Potato Recovery Agent

Perfileva

Ножкина

Ганенко

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…These techniques can be roughly classified into three groups: chemical reduction methods, conversion by physical field (microwave-assisted or laser ablation), and biosynthesis approach. All of them offer some advantages and drawbacks and the majority can be found in the following review papers (Chaudhary et al, 2014(Chaudhary et al, , 2016Wadhwani et al, 2016;Hosnedlova et al, 2018;Sakr et al, 2018;Shi et al, 2020). Chemical reduction methods are simple, economical, fast, and suitable for production on a larger scale.…”

Section: Synthesis Of Senpsmentioning

confidence: 99%

“…Albumins are generally the most abundant globular proteins in serum and provide good biocompatibility while chitosan is a cationic, linear polysaccharide with documented antibacterial properties. Their application in the stabilization of SeNPs was already reported in many papers (Valueva et al, 2007;Chen et al, 2015;Lara et al, 2018;Filipović et al, 2019;Chung et al, 2020;Shi et al, 2020). The third formulation of SeNPs is designed to obtain nanoparticles without using any macromolecule as a stabilizing agent while not compromising parameters such as crystallinity, size, and morphology.…”

Section: Synthesis Of Senpsmentioning

confidence: 99%

“…Nevertheless, the size of the individual particles can be estimated to be lower than in the case of SeNPs-Gluc, around 100 nm. In many previous works, the chemical reduction approach proved to be convenient for producing spherical and amorphous SeNPs (Hosnedlova et al, 2018;Sakr et al, 2018;Shi et al, 2020). Among other parameters (concentrations, the ratio between dispersion phases, mixing method, temperature, etc.…”

Section: Morphological Characterizationmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure

Filipović

Ušjak

Milenković

et al. 2021

Front. Bioeng. Biotechnol.

131

View full text Add to dashboard Cite

Although selenium nanoparticles (SeNPs) have gained attention in the scientific community mostly through investigation of their anticancer activity, a great potential of this nanomaterial was recognized recently regarding its antimicrobial activity. The particle form, size, and surface chemistry have been recognized as crucial parameters determining the interaction of nanomaterials with biological entities. Furthermore, considering a narrow boundary between beneficial and toxic effects for selenium per se, it is clear that investigations of biomedical applications of SeNPs are very demanding and must be done with great precautions. The goal of this work is to evaluate the effects of SeNPs surface chemistry and structure on antimicrobial activity against several common bacterial strains, including Staphylococcus aureus (ATCC 6538), Enterococcus faecalis (ATCC 29212), Bacillus subtilis (ATCC 6633), and Kocuria rhizophila (ATCC 9341), as well as Escherichia coli (ATCC 8739), Salmonella Abony (NCTC 6017), Klebsiella pneumoniae (NCIMB 9111) and Pseudomonas aeruginosa (ATCC 9027), and the standard yeast strain Candida albicans (ATCC 10231). Three types of SeNPs were synthesized by chemical reduction approach using different stabilizers and reducing agents: (i) bovine serum albumin (BSA) + ascorbic acid, (ii) chitosan + ascorbic acid, and (iii) with glucose. A thorough physicochemical characterization of the obtained SeNPs was performed to determine the effects of varying synthesis parameters on their morphology, size, structure, and surface chemistry. All SeNPs were amorphous, with spherical morphology and size in the range 70–300 nm. However, the SeNPs obtained under different synthesis conditions, i.e. by using different stabilizers as well as reducing agents, exhibited different antimicrobial activity as well as cytotoxicity which are crucial for their applications. In this paper, the antimicrobial screening of the selected systems is presented, which was determined by the broth microdilution method, and inhibitory influence on the production of monomicrobial and dual-species biofilm was evaluated. The potential mechanism of action of different systems is proposed. Additionally, the cytotoxicity of SeNPs was examined on the MRC-5 cell line, in the same concentration interval as for antimicrobial testing. It was shown that formulation SeNPs-BSA expressed a significantly lower cytotoxic effect than the other two formulations.

show abstract

“…Thus, polysaccharides applied as carriers to fabricate SeNPs with desired characteristics, such as stability and functionality, using the green chemical method is drawing much attention recently. For example, numerous studies reported that chitosan (CS) could be used as templates to prepare uniform SeNPs and the ligated SeNPs remain stable for over 1 month [ 12 ]. However, the superior properties of CS are limited due to its water insolubility and our previous research also found that CS-SeNPs aggregated under alkaline conditions (pH ≥ 9) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

2022

View full text Add to dashboard Cite

Although selenium nanoparticles (SeNPs) have attracted great attention due to their potential antioxidant activity and low toxicity, the application of SeNPs is still restricted by their poor stability. A combination of polysaccharides and SeNPs is an effective strategy to overcome the limitations. In this study, Polygonatum sibiricum polysaccharide (PSP) was used as a stabilizer to fabricate SeNPs under a simple redox system. Dynamic light scattering, transmission electron microscopy, energy dispersive X-ray, ultraviolet-visible spectroscopy, Fourier transform infrared, and X-ray photoelectron spectrometer were applied to characterize the synthesized PSP-SeNPs. The stability and the antioxidant activity of PSP-SeNPs were also investigated. The results revealed that the zero-valent and well-dispersed spherical PSP-SeNPs with an average size of 105 nm and a negative ζ-potential of −34.9 mV were successfully synthesized using 0.1 mg/mL PSP as a stabilizer. The prepared PSP-SeNPs were stable for 30 days at 4 °C. The decoration of the nanoparticle surface with PSP significantly improved the free radical scavenging ability of SeNPs. Compared to the H2O2-induced oxidative stress model group, the viability of PC-12 cells pretreated with 20 μg/mL PSP-SeNPs increased from 56% to 98%. Moreover, PSP-SeNPs exhibited a higher protective effect on the H2O2-induced oxidative damage on PC-12 cells and lower cytotoxicity than sodium selenite and SeNPs. In summary, these results suggest the great potential of PSP-SeNPs as a novel antioxidant agent in the food or nutraceuticals area.

show abstract

Synthesis, characterization, and biological activity of selenium nanoparticles conjugated with polysaccharides

Cited by 81 publications

References 56 publications

Selenium Nanocomposites in Natural Matrices as Potato Recovery Agent

Selenium Nanocomposites in Natural Matrices as Potato Recovery Agent

Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure

Construction of Polygonatum sibiricum Polysaccharide Functionalized Selenium Nanoparticles for the Enhancement of Stability and Antioxidant Activity

Contact Info

Product

Resources

About