Synthesis, Characterization and Biological Activities of Binuclear Metal Complexes of 2-Benzoylpyridine and Phenyl(Pyridin-2-yl) Methanediol Derived from 1-Phenyl-1-(Pyridin-2-yl)-N-(Pyrimidin-2-yl) Methanimine Dihydrate Schiff Base

Abstract

The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L 1 ) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using 13 C-NMR, 1 H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L 1 ) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L 1 to give binuclear metal complexes of 2-benzoylpyridine (L 2 ) and phenyl(pyridin-2-yl)methanediol (L 3 ) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L 1 ) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L 2 ) and phenyl(pyridin-2-yl)methanediol (L 3 ) from the hydrolysis of L 1 . Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). In vitro antibacterial and antifungal activity against three bacterial strains (Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus) and three fungal stains (Candida albicans, Candida glabrata and Candida parapsilosis) showed moderate biological activity.

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

“…The binuclear complexes of the schiff base with transition metal ions V(IV), Co (II) and Cu (II) were obtained and examined for their antibacterial properties against three bacterial strains Escherichia coli, Klebseilla pneumonia and Staphylococcus aureus. The antifungal activity was also determined against three fungal strains Candida albicans, Candida glabrata and Candida parapsilosis.It was revealed that the schiff base showed good to moderate antibacterial and antifungal activities [53].…”