Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) hydrogels

Wang, X.; Li, Xinmeng; Li, Y.; Zhou, Ying; Fan, Cong; Li, W.; Ma, Shuyue; Fan, Yixuan; Huang, Yanqing; Li, Nan; Liu, Y.

doi:10.1016/j.actbio.2011.07.011

Cited by 47 publications

(39 citation statements)

References 40 publications

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“…[24][25][26][27] Additionally, PEOz can be synthesized easily by the living cationic ring-opening polymerization of 2-ethyl-2-oxazoline and has been approved by the US Food and Drug Administration as food additive. 28 More significantly, PEOz has a favorable pK a , 29 and can be ionized at endo/lysosomal pH. 30 Our previous work and other report demonstrated that this property of PEOz promoted the release of drugs from micelles at the acidic endocytic pH in which PEOz composed the outer shell.…”

Section: Introductionmentioning

confidence: 97%

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Poly(2-ethyl-2-oxazoline)–Doxorubicin Conjugate-Based Dual Endosomal pH-Sensitive Micelles with Enhanced Antitumor Efficacy

Zhou

et al. 2014

Bioconjugate Chem.

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Dual endosomal pH-sensitive micelles were designed and fabricated to deliver doxorubicin (DOX) for treating breast cancer based on a poly(2-ethyl-2-oxazoline) (PEOz)-DOX (PEOz-hyd-DOX) conjugate. PEOz-hyd-DOX was successfully synthesized by connecting DOX to PEOz via an acid cleavable hydrazone linker and self-assembled into nanosized micelles, which further physically encapsulated DOX. The conjugate and DOX-loaded conjugate micelles displayed faster release of DOX at pH 5.0 than at pH 7.4. This pH-dependent release behavior might assist the quick diffusion of DOX from acidic endosomes or lysosomes and the intracellular transfer into the nucleus after internalization, which was confirmed by confocal laser scanning microscopy images. As expected, PEOz-hyd-DOX conjugate and DOX-loaded conjugate micelles maintained cytotoxicity of DOX. In addition, the dual endosomal pH-sensitive micelles were found to substantially enhance antitumor efficacy and reduce side effects compared with free DOX. Therefore, PEOz-hyd-DOX conjugate-based micelles might be potential drug delivery vehicles of DOX for safe and effective breast cancer therapy.

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Section: Introductionmentioning

confidence: 97%

“…These were in good agreement with our previous report. 28 In FTIR spectra of PEOz-COOH ( Figure 3F(a)), the band at 1652 cm −1 was characteristic for the carbonyl vibration of the amide groups. 30 The band at 1736 cm −1 was attributed to the characteristic carbonyl absorption of the terminal carboxyl group.…”

Section: Introductionmentioning

confidence: 98%

Poly(2-ethyl-2-oxazoline)–Doxorubicin Conjugate-Based Dual Endosomal pH-Sensitive Micelles with Enhanced Antitumor Efficacy

Zhou

et al. 2014

Bioconjugate Chem.

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“…Liu and co-workers reported that coupling of a similar type of semitelechelic diblock copolymer, namely OH-endcapped pEtOx-block-poly(lactic acid), with adipoyl chloride as a coupling agent yielded pEtOx-block-poly(lactic acid)-block-pEtOx triblock copolymers that showed temperature-dependent sol-gel-sol transition in water and possessed low cytotoxicity and good biocompatibility [66]. Similarly, Tarvainen and co-workers used OxOx for the coupling of two equivalents of poly(lactic acid), yielding poly(ester amide) copolymers that showed faster hydrolytic degradation for drug release compared to poly(lactic acid) homopolymers [67] (Scheme 4).…”

Section: Poly(2-oxazoline)-co-poly(lactid)smentioning

confidence: 99%

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

2013

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Abstract:The polymer class of poly(2-oxazoline)s currently is under intensive investigation due to the versatile properties that can be tailor-made by the variation and manipulation of the functional groups they bear. In particular their utilization in the biomedic(in)al field is the subject of numerous studies. Given the mechanism of the cationic ring-opening polymerization, a plethora of synthetic strategies exists for the preparation of poly(2-oxazoline)s with dedicated functionality patterns, comprising among others the functionalization by telechelic end-groups, the incorporation of substituted monomers into (co)poly(2-oxazoline)s, and polymeranalogous reactions. This review summarizes the current state-of-the-art of poly(2-oxazoline) preparation and showcases prominent examples of poly(2-oxazoline)-based materials, which are retraced to the desktop-planned synthetic strategy and the variability of their properties for dedicated applications.

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“…The in vitro cytotoxicity of various PTX-loaded micelles to PC-3 cells was evaluated as previously reported [28,29] except that the tested samples were incubated with PC-3 cells for 72 h.…”

Section: In Vitro Cytotoxicity Assessmentmentioning

confidence: 99%

Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles

et al. 2015

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Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) hydrogels

Cited by 47 publications

References 40 publications

Poly(2-ethyl-2-oxazoline)–Doxorubicin Conjugate-Based Dual Endosomal pH-Sensitive Micelles with Enhanced Antitumor Efficacy

Poly(2-ethyl-2-oxazoline)–Doxorubicin Conjugate-Based Dual Endosomal pH-Sensitive Micelles with Enhanced Antitumor Efficacy

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles

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