Synthesis, Characterization, and Antitumour Studies of Metal Chelates of Some Synthetic Curcuminoids

Synthesis and characterization of dual function vanadyl, gallium and indium curcumin complexes for medicinal applications

“…IR spectra of all ligands showed m C@O in the typical 1600-1630 cm À1 range, which shifted to lower energy in the vanadyl complexes of the same ligands. Vanadyl complexes also had no broad band in the 2600-3400 cm À1 range, related to the stretching of intramolecular H in the enol function, as noted for a previously synthesized vanadyl 1,7-diaryl-1,6-heptadiene-3,5-dione, with a different pattern of hydroxylation on the aromatic rings [37]. Vanadyl complexes did show a m V@O medium intensity band at $975-995 cm À1 .…”

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

“…10 The present study suggests that metal complexation significantly increased the cytotoxic.and antitumour activities of compounds. As reported earlier, 9,19,20 the hydroxyl group in the phenyl ring enhances the antitumour activity. This may be the reason for the exceptional activity of 1a and its copper complex.…”

Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

“…IR spectra of ligand curcumin showed mC@O in 1629 cm À1 , which shifted to lower energy in the complexes of the same ligand. And the complexes also had no broad band in the 2600-3400 cm À1 range, related to the stretching of intramolecular H in the enol function [19], which indicated that the carbonyl group of the ligand coordinated to RE (III). New bands occurring in the region 521-525 cm À1 (mRE-O) further supported the formation of RE-O band, the date agree with the literature [20].…”