Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

Song, Yanyan; Xu, Junpeng; Ding, Lei; Hou, Qi; Liu, Jingwang; Zhu, Zao‐Long

doi:10.1016/j.jinorgbio.2008.12.001

Cited by 111 publications

(55 citation statements)

References 19 publications

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“…The hydroxyl free radical formed in the second step leads to DNA damage. This is consistent with the production of hydroxyl radicals by cuprous ions similar to the well known Fenton reaction 21,22 .…”

Section: Electronic Absorption Titrationssupporting

confidence: 89%

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2016

IJPSR

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A mononuclear copper(II) complex [Cu(bpy) 2 (NO 3 )] NO 3 H 2 O (bpy = 2,2'-bipyridine) has been synthesized and characterized based on physico-chemical spectral data. The complex is characterized based on electronic, IR and ESR spectroscopies. The structure of the complex is determined by single crystal X-Ray crystallography. The complex crystallizes in monoclinic space group P-1. Structural analysis reveals that the complex adopts square pyramidal geometry with CuN 4 O chromophore. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. The high binding constant 4.89 x 10 6 M -1 may be due to the strong electrostatic attraction between the cationic complex and the negatively charged phosphodiester backbone of DNA. Nuclease activities of complexes are investigated on double stranded pBR322 plasmid DNA using gel electrophoresis experiments under different conditions. The complex cleaves DNA more effectively in the presence of oxidant.

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Section: Electronic Absorption Titrationssupporting

confidence: 89%

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2016

IJPSR

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“…In the IR spectra of the [M(Cur)(phen)]NO 3 complexes as shown in Fig. 3, the νC=O band of the free curcumin is shifted from 1628 cm -1 to 1625-1598 cm -1 depending on the metal used [20,22]. The presence of an intense band at 1277 cm -1 region which attributed to υ(CO) of phenolic group, confirmed the absence of -OH phenolic in the chelation process.…”

Section: In Vitro Anticancer Screeningmentioning

confidence: 73%

“…The band at 265 and 374 nm corresponds to a π→π * transition, whereas the band at 427 nm can be due either to an n→π* transition or to a combination of π→π* and n→π* transitions [31,32]. The shifts of these bands in the complexes can be detected on the complexes, indicative of involvement of the carbonyl group of curcumin in metal complexation [22] as illustrated in Fig. 5.…”

Section: Characterization Of the Metal-curcumin-phen Mixed Ligand Commentioning

confidence: 99%

“…The lanthanides complexes of Sm(III), Eu(III) and Dy(III) with curcumin and 1,10-phenanthroline-5,6-dione as mixed ligand complexes exhibited effective biological activities [22]. One of these activities were given as the results of agarose gel electrophoresis which suggested that the complex of SmL 3 L' can cleave the plasmid DNA at physiological pH.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

et al. 2014

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Some ternary complexes of curcumin have been synthesized by the reaction of M(II) nitrate with curcumin as primary ligand and 1,10-phenanthroline (phen) as supporting ligand in water/ethanol solution under a nitrogen atmosphere. The composition of the complexes has been characterized by elemental analysis, molar conductivity, thermogravimetric analysis, IR, UV-vis spectroscopy. The results reveal that curcumin ligand coordinates with M(II) in bidentate mode after deprotonation. The supporting ligand (phen) uses its two N atoms in coordination with metal ions in bidentate mode. The general formula of the complexes is [M(Cur)(phen)]NO 3 (M = Ni(II), Co(II), Cu(II) and Z(II)). The results of antibacterial activity indicated that the complexes have good antibacterial ability for the testing bacterium than that of curcumin. Furthermore, the [M(Cur)(phen)]NO 3 complexes were evaluated for its in vitro anticancer activity against hepatocellular carcinoma.

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“…Recent studies have shown that lanthanides could act as scavengers of free radicals and therefore protect cells and tissues from oxidative stress-induced injury [3]. A coordination compound of rare earth and drug may exhibit higher biological activity than that of metal or ligand because of synergetic effects [4,5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral and thermal study of La(III), Nd(III), Sm(III), Eu(III), Gd(III) and Tb(III) complexes with mefenamic acid

Zapała

Kosińska

Woźnicka

et al. 2015

J Therm Anal Calorim

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New binuclear complexes of La(III), Nd(III), Sm(III), Eu(III), Gd(III) and Tb(III) ions with mefenamic acid were obtained in solid phase. For all compounds considered, complexation occurs at pH 6-6.5. The analyzed complexes were characterized on the basis of chemical and elemental analyses, molar conductance, UVVis, IR and 1H NMR spectroscopies as well as thermoanalytical techniques. According to the research results, the molecular formula of the complexes is Ln 2 (C 15 H 14 NO 2 ) 3 (OH) 3 9nH 2 O, with the exception of the La(III) complex which has the formula La 2 (C 15 H 14 NO 2 ) 5 (OH). The results show that only the carboxyl group is involved in the coordination of the rare earth ions in the bidentate mode. Coordination does not occur through the nitrogen atom. All the complexes are soluble in DMSO, and they are nonelectrolytes. The TG-FTIR technique was employed in order to study a decomposition pathway of the obtained compounds. The received results provide information on the composition, thermal stability, thermal decomposition, as well as the gaseous products that evolved during the thermal decomposition of the considered compounds.

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Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

Cited by 111 publications

References 19 publications

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Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

Synthesis, spectral and thermal study of La(III), Nd(III), Sm(III), Eu(III), Gd(III) and Tb(III) complexes with mefenamic acid

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