Synthesis, characterization and antitumor activity of the germanium-quercetin complex

Zhai, Guangyu; Zhu, Wei; Duan, Yufeng; Wen-tao, QU; Yan, Zitong

doi:10.1515/mgmc-2012-0026

Cited by 20 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoid metal complexes oen display antiproliferative activity against cancerous cell lines. 55,245 Rare earth metal complexes of quercetin, for example, were shown to affect DNA transcription and to inhibit tumor cell growth by binding to DNA. 55,246 Oen the activity of the complex is superior to the activity of the avonoid alone.…”

Section: Cytostatic Activitymentioning

confidence: 99%

Properties and applications of flavonoid metal complexes

2015

View full text Add to dashboard Cite

show abstract

Section: Cytostatic Activitymentioning

confidence: 99%

Properties and applications of flavonoid metal complexes

2015

View full text Add to dashboard Cite

show abstract

“…The quercetin-Ge(IV) complex 72 , obtained by reacting quercetin with germanium dioxide in basic medium [ 79 ], proved to possess significant in vitro cell growth inhibitory activity in human lung (SPC-A-1), human esophageal (EC9706), HeLa, and PC-3 cancer cell lines ( Table 14 ), but these data lack of a comparative relation to quercetin. Compound 72 showed apoptosis-inducing effects, too.…”

Section: Synthesis and Anticancer-related Activities Of Quercetin mentioning

confidence: 99%

Research Progress in the Modification of Quercetin Leading to Anticancer Agents

et al. 2017

View full text Add to dashboard Cite

The flavonoid quercetin (3,3′,4′,5,7-pentahydroxyflavone) is widely distributed in plants, foods, and beverages. This polyphenol compound exhibits varied biological actions such as antioxidant, radical-scavenging, anti-inflammatory, antibacterial, antiviral, gastroprotective, immune-modulator, and finds also application in the treatment of obesity, cardiovascular diseases and diabetes. Besides, quercetin can prevent neurological disorders and exerts protection against mitochondrial damages. Various in vitro studies have assessed the anticancer effects of quercetin, although there are no conclusive data regarding its mode of action. However, low bioavailability, poor aqueous solubility as well as rapid body clearance, fast metabolism and enzymatic degradation hamper the use of quercetin as therapeutic agent, so intense research efforts have been focused on the modification of the quercetin scaffold to obtain analogs with potentially improved properties for clinical applications. This review gives an overview of the developments in the synthesis and anticancer-related activities of quercetin derivatives reported from 2012 to 2016.

show abstract

“…The results of the present study suggest that a stoichiometric ratio to obtain a PGG-germanium precipitate is strictly defined. Certain studies have found that the ortho-dihydroxyl group on the flavonoid B-ring of condensed tannins can complex with germanium to form a tris-chelate (Zhai et al 2018). Compared with condensed tannins, hydrolyzable tannins have a higher number of ortho-dihydroxyl groups at the same molecular weight; hence, hydrolyzable tannins can complex with a higher number of germanium ions.…”

Section: Pgg-germanium Precipitationmentioning

confidence: 99%

Binding and precipitation of germanium(IV) by four hydrolyzable tannins

Liu¹,

Zhang²,

Xu³

et al. 2020

BioRes

View full text Add to dashboard Cite

The complexation conditions and complex characteristics of 1,2,3,4,6-O-galloyl-β-D-glucose (PGG), a typical hydrolyzable tannin, and Ge4+ were studied. Species of the PGG-Al3+ complex formed in various water-methanol systems (20% to 100%, v/v) were investigated. The results showed that the amount of PGG and Ge in the precipitate was substantially influenced by the initial Ge/PGG molar ratio. The highest amount of the precipitate was obtained at the initial Ge/PGG molar ratio of 1:2 and the stoichiometric ratio (Ge/PGG molar ratio) of the precipitates gradually decreased from 0.72 to 0.30 concomitant to a decrease in the initial Ge/PGG molar ratio from 1:1 to 1:4. Precipitation experiments of Ge4+ by four hydrolyzable tannins from Chinese gallnut (TA), chestnut shell (CT), Platycarya strobilacea infructescence (PT), and Valonia (VT) were compared. The results indicated that the amount of the precipitate was substantially influenced by the initial tannin/Ge ratio and pH and was slightly influenced by the reaction time. The highest amount of the precipitate was obtained at the initial tannin/Ge mass ratio of 2.3:1 and pH 7.2. Stability of the TA-Ge, CT-Ge, VT-Ge, and PT-Ge precipitates in several solutions was determined. The TA-Ge precipitates showed relatively high stability in the test solvents compared to that of other tannins.

show abstract

Synthesis, characterization and antitumor activity of the germanium-quercetin complex

Cited by 20 publications

References 0 publications

Properties and applications of flavonoid metal complexes

Properties and applications of flavonoid metal complexes

Research Progress in the Modification of Quercetin Leading to Anticancer Agents

Binding and precipitation of germanium(IV) by four hydrolyzable tannins

Contact Info

Product

Resources

About