Properties and applications of flavonoid metal complexes

Abstract

Flavonoid metal complexes have a wide spectrum of activities as well as potential and actual applications.

Study of the Cytotoxicity Effect of New Co(II) and Mn(II) Complexes of Flavon on Cancer <i>(</i>Cell Line <i>RD)</i> and Antimicrobial Activity

“…Such increased activity of the complexes can be explained based on Overtones concept [19] and the tweedy chelation theory [20]. Moreover, the copper complexes were more active than the other complexes against the tested microorganisms as shown in scheme (1).…”

The Influence of Mg(II) and Ca(II) Ions on Rutin Autoxidation in Weakly Alkaline Aqueous Solutions

“…This bathochromic shift of absorption bands was caused by the partial deprotonation of rutin molecule with increasing pH value of solution as in the case of similar flavonoid molecules (20). Complexation of flavonoids with metal ion causes further bathochromic shift of characteristic absorption bands (19), and in the presence of Mg(II) and Ca(II) ions absorption maximum of the cinnamoyl band shifted to 406 nm and 395 nm, respectively, while there was almost no shift of the benzoyl band. As in the case of quercetin complexation with Mg(II) and Ca(II) ions (21), larger bathochromic shift was caused by the presence of Mg(II) ion which may be explained by its higher ionic potential (charge/ionic radius ratio) in comparison to Ca(II) ion.…”

“…Two absorption bands characteristic for flavonoids, the benzoyl band in the 240-280 nm range and the cinnamoyl band in the 320-385 nm range (19) , appear in the spectra shown in Figure 2. However, at pH 8.4 in the absence of metal ions absorption maxima of these bands shifted to higher wavelengths (271 and 385 nm) in comparison to rutin in acidic solutions (256 and 356 nm at pH 3).…”

New Look on 3-Hydroxyiminoflavanone and Its Palladium(II) Complex: Crystallographic and Spectroscopic Studies, Theoretical Calculations and Cytotoxic Activity

“…Moreover, the oxime hydrogen atoms are lost and the ligand occurs in the complex as 3-nitrosoflavanone. between flavonoids and metal ions [9,10]. In addition, complexes with nitrogen-containing ligands are the subject of intensive biological evaluation in the search for less toxic and more selective anticancer agents [11].…”