Synthesis, Characterization and Antitumor Activity of Some New Oganotellurium Compounds Containing Azomethine Group, Part One

Abstract

New tellurated schiff bases were synthesized by the reaction of the corresponding mercurated Schiff bases compounds A1-A3 with tellurium tetrabromide in 1:1 mole ratio and that gave organyltellurium tribromides A4-A6. On the other hand, when mercurated schiff bases and tellurium tetrabromide brought together in 2:1 mole ratio gave diorganyltellurium dibromides compounds A10-A12 followed by reduction with hydrazine hydrate gave new diorganyl tellurides A13-A15. Reduction of compounds A4-A6 by hydrazine hydrate gave new ditellurides A7-A9. All compounds were characterized by elemental analysis, IR, 1H , 13C NMR, HSQC-NMR and mass spectra. Invitro anti-tumor bioactivity of some compounds were tested.

New Mercurated and Tellurated Sulpha Compounds: Synthesis, Invitro Anticancer Study and DFT Calculation.

“…λ 4 -tellanyl)benzenesulfonic acid 2 (1.79 g, 4 mmol) of tellurium tetrabromide was mixed with an equivalent molar amount of (2-amino-5-sulfophenyl) mercury(II)chloride 1 weighing 1.63 g., 4 mmol in 40 mL of 1,4-dioxane and refluxed for 6 hours under argon atmosphere. Upon cooling, a 1:2 addition compound of mercury(II) halide and dioxane was isolated as white sheets and filtered.…”

“…Synthesising several organotellurium compounds using transmetallation of organomercury substances has been widely studied and reported in several publications [4][5][6][7]. Aromatic compounds, when reacting with tellurium tetrahalides, undergo a direct substitution reaction, and the obtained yield is low.…”

Molecular structure, vibrational spectroscopic and HOMO/LUMO studies of some organotellurium compounds by quantum chemical investigations

“…The compounds a1-a10 were prepared according to previously published procedure [13,14]. Infrared spectra were recorded as KBr discs in the range of 4000-400 cm -1 using a Shimadzu FT-IR spectrophotometer at Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Iraq.…”