Synthesis, characterization and antiradiation properties of the tryptophanates of cobalt (II), manganese (II), copper (II) and zinc

Abstract

Aim. In order to study the radioprotective activity were were obtained in the tryptophanates of cobalt (II), manganese (II), copper (II) and zinc. Methods. The composition and structure of the complexes were studied by elemental, thermogravimetric analyzes and IR infrared spectroscopy. To determine the presence of the Radioprotective Properties of the Co (II), Mn (II), Cu (II), Zn complexes with tryptophane, a test was conducted for the 30-day survival of irradiated animals. Results. The results of thermogravimetric studies have shown that the final product of the thermal decomposition of all compounds is metal oxide, respectively. The method of IR spectroscopy showed that the ligands in the composition of the metal (II) complexes enter the neutral form and coordinate with the complexing agent through the nitrogen atom. The results of experiments with complexes showed that they have noticeable radioprotective activity. The radioprotective activity of Co (II) complexes with tryptophan is 55%, Mn (II) with tryptophan 50%, Cu (II) with tryptophan 40%, and Zn 30%. They improve the survival and average life expectancy of lethally irradiated mice, not reaching the level of the known cystamine radioprotector, which is 80%. Conclusions. The data obtained by us testify to the prospects of using the complexes of Co (II), Mn (II), Cu (II), Zn with tryptophan for preventive purposes and in order to prevent local radiation injuries.
 Keywords: tryptophan-metal complexes, IR spectroscopy, thermogravimetry, complex compounds, radioprotective properties.

Protective properties of the nickel (II) complex with tryptophan

“…Toxicity assessment Experiments were carried out on Wistar rats of both sexes weighing 150-180 g. Acute toxicity of the complex was determined according to the method [6,10], with a single intragastric administration in doses in a final volume of 10 ml / kg. The nickel complex was injected once intragastrically in volumes of 1.0-5.0 ml / kg.…”